Acceptability of the RTS, S malaria vaccine and associated factors among caregivers of children under 25 months in Soa Health District, Cameroon: a community-based cross-sectional study.
7 affiliations
- 1Higher Institute of Medical Technology, Yaoundé, Cameroon. [email protected].
- 2Challenges Initiative Solutions, Yaoundé, Cameroon. [email protected].
- 3Higher Institute of Medical Technology, Yaoundé, Cameroon.
- 4Challenges Initiative Solutions, Yaoundé, Cameroon.
- 5A Hand to Humanity, Yaoundé, Cameroon.
- 6University of Yaoundé 1, Yaoundé, Cameroon.
- 7School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.
Abstract
Background
Malaria remains a major cause of morbidity and mortality in sub-Saharan Africa. In Cameroon, malaria accounts for 48% of all hospital admissions, 30% of morbidity, and 67% of childhood mortality per year. Despite the introduction of RTS, S in several African countries, real-world evidence on community acceptability following vaccine rollout remains limited, particularly at the district level. Understanding caregivers' willingness to vaccinate is critical for optimizing uptake and guiding context-specific implementation strategies.Methods
A community-based cross-sectional study was conducted between March and November 2024 in the Soa Health District (HD). A total of 541 caregivers of children under 25 months were recruited using a non-probability convenience sampling method. Data were collected using a structured pre-tested questionnaire and analysed using R software. Modified Poisson regression models with robust variance estimation was used to obtain crude and adjusted prevalence ratio (CPR and APR) with 95% confidence intervals (95% CIs), a statistical significance was set at p-value < 0.05.Results
Among the 541 caregivers, 73.4% expressed willingness to vaccinate their children against malaria. Higher vaccine acceptability was independently associated with residing in Koulou (APR = 1.4; 95% CI: 1.1-2.0), Ngali 2 (APR = 10.6; 95% CI: 1.2-2.2), and Soa (APR = 1.6; 95% CI: 1.1-2.2) compared with Ntsouessong; female sex (APR = 1.2; 95% CI: 1.0-1.3); origine from the North-West, South-West, West, and Littoral regions (APR = 1.2; 95% CI: 1.1-1.4); use street medicine (APR = 1.3; 95% CI: 1.0-1.6) or prescribed medicine (APR = 10.2; 95% CI: 10.0-1.5) rather than traditional medicine for malaria treatment; prior awareness of the malaria vaccine (APR = 1.2; 95% CI: 1.1-1.4). All p < 0.05. CONCLUSION: Acceptability of the malaria vaccine among caregivers in the Soa HD was relatively high and was significantly influenced by geographic location, sex, region, health-seeking behaviour, and awareness of the vaccine. Targeted health education and culturally sensitive community engagement strategies are essential to improve vaccine acceptability and support the successful scale-up of malaria vaccination programmes in Cameroon and other endemic settings.Clinical trial registration
Not applicable.
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BibTeX
@article{dang2026acceptability,
title = {{Acceptability of the RTS, S malaria vaccine and associated factors among caregivers of children under 25 months in Soa Health District, Cameroon: a community-based cross-sectional study.}},
author = {Ludrique Dang and Fabien Fouda Ombogo and Bime Brenda Burinyuy and Gilles Tounsi Kamdem and Caryl Caleb Youmbi Menougong},
journal = {BMC public health},
year = {2026},
month = aug,
doi = {10.1186/s12889-026-28884-y},
url = {https://europepmc.org/article/MED/43009886},
note = {CC BY},
}
RIS
TY - JOUR
TI - Acceptability of the RTS, S malaria vaccine and associated factors among caregivers of children under 25 months in Soa Health District, Cameroon: a community-based cross-sectional study.
AU - Ludrique Dang
AU - Fabien Fouda Ombogo
AU - Bime Brenda Burinyuy
AU - Gilles Tounsi Kamdem
AU - Caryl Caleb Youmbi Menougong
PY - 2026
DA - 2026/08/04
JO - BMC public health
DO - 10.1186/s12889-026-28884-y
UR - https://europepmc.org/article/MED/43009886
AB - Background Malaria remains a major cause of morbidity and mortality in sub-Saharan Africa. In Cameroon, malaria accounts for 48% of all hospital admissions, 30% of morbidity, and 67% of childhood mortality per year. Despite the introduction of RTS, S in several African countries, real-world evidence on community acceptability following vaccine rollout remains limited, particularly at the district level. Understanding caregivers' willingness to vaccinate is critical for optimizing uptake and guiding context-specific implementation strategies.Methods A community-based cross-sectional study was conducted between March and November 2024 in the Soa Health District (HD). A total of 541 caregivers of children under 25 months were recruited using a non-probability convenience sampling method. Data were collected using a structured pre-tested questionnaire and analysed using R software. Modified Poisson regression models with robust variance estimation was used to obtain crude and adjusted prevalence ratio (CPR and APR) with 95% confidence intervals (95% CIs), a statistical significance was set at p-value < 0.05.Results Among the 541 caregivers, 73.4% expressed willingness to vaccinate their children against malaria. Higher vaccine acceptability was independently associated with residing in Koulou (APR = 1.4; 95% CI: 1.1-2.0), Ngali 2 (APR = 10.6; 95% CI: 1.2-2.2), and Soa (APR = 1.6; 95% CI: 1.1-2.2) compared with Ntsouessong; female sex (APR = 1.2; 95% CI: 1.0-1.3); origine from the North-West, South-West, West, and Littoral regions (APR = 1.2; 95% CI: 1.1-1.4); use street medicine (APR = 1.3; 95% CI: 1.0-1.6) or prescribed medicine (APR = 10.2; 95% CI: 10.0-1.5) rather than traditional medicine for malaria treatment; prior awareness of the malaria vaccine (APR = 1.2; 95% CI: 1.1-1.4). All p < 0.05. CONCLUSION: Acceptability of the malaria vaccine among caregivers in the Soa HD was relatively high and was significantly influenced by geographic location, sex, region, health-seeking behaviour, and awareness of the vaccine. Targeted health education and culturally sensitive community engagement strategies are essential to improve vaccine acceptability and support the successful scale-up of malaria vaccination programmes in Cameroon and other endemic settings.Clinical trial registration Not applicable.
SN - 1471-2458
ER -