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Peer-reviewedCC BY 4.0PLOS One

Predicting risk of progression of early to late AMD in the aging eye through imaging and multimodal evaluation: PRIME study protocol

  • Ali Forouhari1
  • Chui Ming Gemmy Cheung2
  • Low Lian Leng3
  • Noa Gilead4
  • Usha Chakravarthy
  • Kelvin Yi Chong Teo
4 affiliations
  1. 1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
  2. 2Duke-NUS Eye ACP, National University of Singapore, Singapore
  3. 3Singapore General Hospital, Singapore
  4. 4Centre for Public Health, Faculty of Medicine and Health Sciences, Queen’s University Belfast, Belfast, United Kingdom
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Abstract

Background: Age-related macular degeneration (AMD) is a leading cause of vision impairment globally and demonstrates substantial variation regarding progression and clinical subtypes across populations. This paper describes the methodology of our study, designed to establish the natural history of AMD in Asian elderly and to identify predictors of progression from early signs of AMD to late AMD over a 5-year period. Methods: This prospective, longitudinal cohort study aims to recruit 1500 participants from community-based cohorts in Singapore, with a follow-up duration of 5 years. Eligible participants are adults aged 55 years or older without severe systemic illness that would preclude participation. Discussion: There is a paucity of data on the progression of AMD and optimal referral thresholds, particularly in Asian populations. This community-based cohort, representative of the general population, will generate one of the largest longitudinal datasets on AMD in Asia and aims to inform future screening strategies.

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Cite

BibTeXRIS
BibTeX
@article{forouhari2026predicting,
  title = {{Predicting risk of progression of early to late AMD in the aging eye through imaging and multimodal evaluation: PRIME study protocol}},
  author = {Ali Forouhari and Chui Ming Gemmy Cheung and Low Lian Leng and Noa Gilead and Usha Chakravarthy and Kelvin Yi Chong Teo},
  journal = {PLOS One},
  year = {2026},
  month = aug,
  doi = {10.1371/journal.pone.0355953},
  url = {https://doi.org/10.1371/journal.pone.0355953},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Predicting risk of progression of early to late AMD in the aging eye through imaging and multimodal evaluation: PRIME study protocol
AU  - Ali Forouhari
AU  - Chui Ming Gemmy Cheung
AU  - Low Lian Leng
AU  - Noa Gilead
AU  - Usha Chakravarthy
AU  - Kelvin Yi Chong Teo
PY  - 2026
DA  - 2026/08/31
JO  - PLOS One
DO  - 10.1371/journal.pone.0355953
UR  - https://doi.org/10.1371/journal.pone.0355953
AB  - Background: Age-related macular degeneration (AMD) is a leading cause of vision impairment globally and demonstrates substantial variation regarding progression and clinical subtypes across populations. This paper describes the methodology of our study, designed to establish the natural history of AMD in Asian elderly and to identify predictors of progression from early signs of AMD to late AMD over a 5-year period. Methods: This prospective, longitudinal cohort study aims to recruit 1500 participants from community-based cohorts in Singapore, with a follow-up duration of 5 years. Eligible participants are adults aged 55 years or older without severe systemic illness that would preclude participation. Discussion: There is a paucity of data on the progression of AMD and optimal referral thresholds, particularly in Asian populations. This community-based cohort, representative of the general population, will generate one of the largest longitudinal datasets on AMD in Asia and aims to inform future screening strategies.
SN  - 1932-6203
ER  -