Intravenous Fat Emulsion Administration and Short-Term Lipid Profiles Under a Standardized Clinical Pathway After Gastrectomy: A Retrospective Observational Study
4 affiliations
- 1Department of Pharmacy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
- 2Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan
- 3UNISMILE Pharmacy Komagome Hospital Front Store, UNISMILE Co., Ltd., 5-50-1 Sendagi, Bunkyo-ku, Tokyo 113-0022, Japan
- 4Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan
Abstract
Background/Objectives: Real-world data on intravenous fat emulsion administration and postoperative lipid profiles under standardized clinical pathways are limited. We described administration practices and short-term lipid profiles after gastrectomy. Methods: This single-center retrospective study included patients who underwent gastrectomy for gastric cancer between August and December 2020 and received postoperative fat emulsion. The pathway specified 50 g/day of a 20% soybean oil-based emulsion, starting on postoperative day (POD) 1, generally for five days. Dose, infusion duration, weight-adjusted infusion rate, and serum triglyceride (TG) and total cholesterol (T-Cho) levels were assessed descriptively. Lipid elevations were graded using the Common Terminology Criteria for Adverse Events version 5.0. Results: Among 89 patients, 85 received fat emulsion and were analyzed. The median infusion rate was 0.16 g/kg/h (range, 0.09–0.34); 83 patients (97.6%) received rates >0.1 g/kg/h, including 67 (78.8%) at >0.1 to ≤0.2 g/kg/h. No grade ≥2 TG or T-Cho elevations were observed in available measurements on POD 3 or POD 7. Median TG was 107.5 mg/dL before surgery and 119 mg/dL on POD 7; corresponding T-Cho values were 188 and 146 mg/dL. Outpatient TG measurements were available for only four patients. Conclusions: These findings describe short-term lipid profiles under a fixed-dose postoperative nutritional pathway. They do not establish the safety of infusion rates exceeding 0.1 g/kg/h or define a safe upper infusion-rate threshold.
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BibTeX
@article{kobayashi2026intravenous,
title = {{Intravenous Fat Emulsion Administration and Short-Term Lipid Profiles Under a Standardized Clinical Pathway After Gastrectomy: A Retrospective Observational Study}},
author = {Kazuo Kobayashi and Satoshi Ida and Masanari Tsuji and Takeshi Aoyama and Takashi Yokokawa and Yoshikazu Tateai and Shuichi Watabe and Hisanori Shimizu and Souya Nunobe and Masakazu Yamaguchi},
journal = {Nutrients},
year = {2026},
month = oct,
doi = {10.3390/nu18213566},
url = {https://www.mdpi.com/2072-6643/18/21/3566},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Intravenous Fat Emulsion Administration and Short-Term Lipid Profiles Under a Standardized Clinical Pathway After Gastrectomy: A Retrospective Observational Study
AU - Kazuo Kobayashi
AU - Satoshi Ida
AU - Masanari Tsuji
AU - Takeshi Aoyama
AU - Takashi Yokokawa
AU - Yoshikazu Tateai
AU - Shuichi Watabe
AU - Hisanori Shimizu
AU - Souya Nunobe
AU - Masakazu Yamaguchi
PY - 2026
DA - 2026/10/28
JO - Nutrients
DO - 10.3390/nu18213566
UR - https://www.mdpi.com/2072-6643/18/21/3566
AB - Background/Objectives: Real-world data on intravenous fat emulsion administration and postoperative lipid profiles under standardized clinical pathways are limited. We described administration practices and short-term lipid profiles after gastrectomy. Methods: This single-center retrospective study included patients who underwent gastrectomy for gastric cancer between August and December 2020 and received postoperative fat emulsion. The pathway specified 50 g/day of a 20% soybean oil-based emulsion, starting on postoperative day (POD) 1, generally for five days. Dose, infusion duration, weight-adjusted infusion rate, and serum triglyceride (TG) and total cholesterol (T-Cho) levels were assessed descriptively. Lipid elevations were graded using the Common Terminology Criteria for Adverse Events version 5.0. Results: Among 89 patients, 85 received fat emulsion and were analyzed. The median infusion rate was 0.16 g/kg/h (range, 0.09–0.34); 83 patients (97.6%) received rates >0.1 g/kg/h, including 67 (78.8%) at >0.1 to ≤0.2 g/kg/h. No grade ≥2 TG or T-Cho elevations were observed in available measurements on POD 3 or POD 7. Median TG was 107.5 mg/dL before surgery and 119 mg/dL on POD 7; corresponding T-Cho values were 188 and 146 mg/dL. Outpatient TG measurements were available for only four patients. Conclusions: These findings describe short-term lipid profiles under a fixed-dose postoperative nutritional pathway. They do not establish the safety of infusion rates exceeding 0.1 g/kg/h or define a safe upper infusion-rate threshold.
SN - 2072-6643
ER -