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Peer-reviewedCC BY 4.0Nutrients

Radish Red Anthocyanins Extract Attenuated High-Fat Diet-Induced Aging in Association with Improving Antioxidant Defense and Gut Microbiota–Metabolite Changes in Drosophila Melanogaster

  • Zhenxia Li1
  • Can Xu1
  • Qingjing Liao1
  • Fayin Ye1
  • Fasheng Lv2
  • Cai Peng2
  • Zhenyu Chen3
  • Lin Lei1
  1. 1College of Food Science, Southwest University, No. 2 Tiansheng Road, Chongqing 400715, China
  2. 2Southeast Chongqing Academy of Agricultural Sciences, Fuling Academy of Southwest University, Chongqing 408000, China
  3. 3School of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China
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Abstract

Background: Radish red anthocyanins (RRA) extract, derived from geographical-indication Yanzhi radish from Fuling, Chongqing, China, was investigated to attenuate high-fat diet- induced aging in Drosophila melanogaster. RRA extract, rich in acylated pelargonidin- and cyanidin-based anthocyanins, extended lifespan without reducing food intake, improved reproductive and locomotor performance, raised superoxide dismutase and catalase activities, whereas reduced malondialdehyde accumulation. Mthoths: Using a Drosophila melanogaster model, we investigated the anti-aging effects of RRA extract and its potential underlying mechanisms. Results: It enhanced resistance to starvation, cold, and heat stress, reduced age-associated intestinal leakage, and regulated antioxidant- and autophagy-related genes, particularly manganese superoxide dismutase (SOD2) and autophagy-related 8a (Atg8a). Gut microbiota analysis showed high-dose RRA supplementation selectively increased Pseudomonas-related amplicon sequence variants 30 and 31. Untargeted metabolomics showed variations in glycerophospholipid, sphingolipid, nucleotide, and amino acid metabolism. Correlation results linked these Pseudomonas-related bacteria with lipid/nucleotide-related metabolites and stress resistance. Conclusions: RRA extract alleviated diet-induced aging through antioxidant defense, intestinal protection, and gut microbiota–metabolite modulation, providing a research basis for high-value utilization of Yanzhi radish anthocyanins.

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Cite

BibTeXRIS
BibTeX
@article{li2026radish,
  title = {{Radish Red Anthocyanins Extract Attenuated High-Fat Diet-Induced Aging in Association with Improving Antioxidant Defense and Gut Microbiota–Metabolite Changes in Drosophila Melanogaster}},
  author = {Zhenxia Li and Can Xu and Qingjing Liao and Fayin Ye and Fasheng Lv and Cai Peng and Zhenyu Chen and Lin Lei},
  journal = {Nutrients},
  year = {2026},
  month = oct,
  doi = {10.3390/nu18213499},
  url = {https://www.mdpi.com/2072-6643/18/21/3499},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Radish Red Anthocyanins Extract Attenuated High-Fat Diet-Induced Aging in Association with Improving Antioxidant Defense and Gut Microbiota–Metabolite Changes in Drosophila Melanogaster
AU  - Zhenxia Li
AU  - Can Xu
AU  - Qingjing Liao
AU  - Fayin Ye
AU  - Fasheng Lv
AU  - Cai Peng
AU  - Zhenyu Chen
AU  - Lin Lei
PY  - 2026
DA  - 2026/10/24
JO  - Nutrients
DO  - 10.3390/nu18213499
UR  - https://www.mdpi.com/2072-6643/18/21/3499
AB  - Background: Radish red anthocyanins (RRA) extract, derived from geographical-indication Yanzhi radish from Fuling, Chongqing, China, was investigated to attenuate high-fat diet- induced aging in Drosophila melanogaster. RRA extract, rich in acylated pelargonidin- and cyanidin-based anthocyanins, extended lifespan without reducing food intake, improved reproductive and locomotor performance, raised superoxide dismutase and catalase activities, whereas reduced malondialdehyde accumulation. Mthoths: Using a Drosophila melanogaster model, we investigated the anti-aging effects of RRA extract and its potential underlying mechanisms. Results: It enhanced resistance to starvation, cold, and heat stress, reduced age-associated intestinal leakage, and regulated antioxidant- and autophagy-related genes, particularly manganese superoxide dismutase (SOD2) and autophagy-related 8a (Atg8a). Gut microbiota analysis showed high-dose RRA supplementation selectively increased Pseudomonas-related amplicon sequence variants 30 and 31. Untargeted metabolomics showed variations in glycerophospholipid, sphingolipid, nucleotide, and amino acid metabolism. Correlation results linked these Pseudomonas-related bacteria with lipid/nucleotide-related metabolites and stress resistance. Conclusions: RRA extract alleviated diet-induced aging through antioxidant defense, intestinal protection, and gut microbiota–metabolite modulation, providing a research basis for high-value utilization of Yanzhi radish anthocyanins.
SN  - 2072-6643
ER  -