Spectrum-dependent dysbiosis and recovery patterns of the gut microbiota following antimicrobial exposure
Abstract
Broad-spectrum antimicrobials profoundly alter gut microbial ecosystems; however, post-antimicrobial recovery remains incompletely understood. Here, we used a short-term oral exposure model in mice treated with clindamycin, moxifloxacin, or ceftriaxone, representing antimicrobials with distinct antibacterial spectra. Each antimicrobial induced distinct patterns of gut microbiota perturbation and cecal enlargement. At day 0, immediately after antimicrobial exposure, antimicrobial-specific differences in microbial composition and diversity were observed, followed by distinct recovery trajectories through days 3 and 5. Clindamycin induced sustained dysbiosis with limited recovery, whereas ceftriaxone caused pronounced initial disruption followed by partial recovery by day 5. Moxifloxacin produced transient perturbation with greater recovery of microbial diversity. Together, analyses of taxonomic composition, α-diversity, and β-diversity demonstrated that both the magnitude of the initial perturbation and early recovery were antimicrobial dependent. These findings delineate spectrum-dependent patterns of gut microbiota disruption and early recovery following antimicrobial exposure and highlight antimicrobial-specific effects on gut microbial resilience.
Related
- 6:2 Cl-PFESA induces sex-dependent lung inflammation through NLRP12 inflammasome activation and pulmonary microbiota dysbiosis
- Epigenetic Regulation and Gut Microbiota Dysbiosis in Age-Related Macular Degeneration
- Gut microbiota-mediated Th17/Treg regulation in osteoporotic fracture: from postmenopausal dysbiosis to callus repair
- Research progress on the mechanisms by which gut microbiota dysbiosis remodels the bone marrow neuroimmune microenvironment to drive age-related osteoporosis
- Colonization of the gut microbiota with Akkermansia muciniphila ameliorates dysbiosis-mediated transplant arterial injury in female mice
BibTeX
@article{yoon2026spectrumdependent,
title = {{Spectrum-dependent dysbiosis and recovery patterns of the gut microbiota following antimicrobial exposure}},
author = {Eun-Jeong Yoon and Nakyeoung Ha and Min Cheol Jeong},
journal = {iScience},
year = {2026},
month = oct,
doi = {10.1016/j.isci.2026.118069},
url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03452-8},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Spectrum-dependent dysbiosis and recovery patterns of the gut microbiota following antimicrobial exposure
AU - Eun-Jeong Yoon
AU - Nakyeoung Ha
AU - Min Cheol Jeong
PY - 2026
DA - 2026/10/28
JO - iScience
DO - 10.1016/j.isci.2026.118069
UR - https://www.cell.com/iscience/fulltext/S2589-0042(26)03452-8
AB - Broad-spectrum antimicrobials profoundly alter gut microbial ecosystems; however, post-antimicrobial recovery remains incompletely understood. Here, we used a short-term oral exposure model in mice treated with clindamycin, moxifloxacin, or ceftriaxone, representing antimicrobials with distinct antibacterial spectra. Each antimicrobial induced distinct patterns of gut microbiota perturbation and cecal enlargement. At day 0, immediately after antimicrobial exposure, antimicrobial-specific differences in microbial composition and diversity were observed, followed by distinct recovery trajectories through days 3 and 5. Clindamycin induced sustained dysbiosis with limited recovery, whereas ceftriaxone caused pronounced initial disruption followed by partial recovery by day 5. Moxifloxacin produced transient perturbation with greater recovery of microbial diversity. Together, analyses of taxonomic composition, α-diversity, and β-diversity demonstrated that both the magnitude of the initial perturbation and early recovery were antimicrobial dependent. These findings delineate spectrum-dependent patterns of gut microbiota disruption and early recovery following antimicrobial exposure and highlight antimicrobial-specific effects on gut microbial resilience.
SN - 2589-0042
ER -