Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 41 min ago
Peer-reviewedCC BY-NC-NDClinical and experimental medicine

Influence of marital status on clinical outcomes in peripheral T-cell lymphoma: a population-based analysis.

  • Gengcong Luo1
  • Yongqing Li1
  • Chen Wu2,3
  • Hongbin Jiang1
  • Chunjia Zhang1
  • Xiaoling Zheng1
  • Xitian Chen4
  • Zhao Wang5
  • Weilin Xia6
6 affiliations
  1. 1Department of Hematology, Jieyang People's Hospital, Jieyang Cancer Center, Jieyang, 522000, Guangdong, China.
  2. 2The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
  3. 3Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
  4. 4Department of Hematology, Jieyang People's Hospital, Jieyang Cancer Center, Jieyang, 522000, Guangdong, China. [email protected].
  5. 5State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China. [email protected].
  6. 6Department of Hematology, Jieyang People's Hospital, Jieyang Cancer Center, Jieyang, 522000, Guangdong, China. [email protected].
Read full textPDFDOICite

Abstract

Peripheral T-cell lymphoma (PTCL) is an aggressive malignancy with poor prognosis that requires intensive systemic therapy, highlighting the potential impact of psychosocial factors on disease management and clinical outcomes. In this population-based study using SEER data from 2013 to 2022, we identified 5,919 patients newly diagnosed with PTCL. Propensity score matching (PSM) was applied to control for baseline differences, and survival outcomes were evaluated using Kaplan-Meier analysis and Cox proportional hazards models. Unmarried patients were more likely to be female, younger, and of non-White race. Survival analysis demonstrated that unmarried patients had significantly lower 5-year overall survival (OS: 40.7% vs. 45.7%; P < 0.001) and cause-specific survival (CSS: 49.9% vs. 53.8%; P = 0.0018). This survival disparity persisted after PSM (n = 4,481), with significantly lower 5-year OS (40.0% vs. 47.9%, P < 0.001) and CSS (49.1% vs. 55.3%, P < 0.001) in unmarried patients. On multivariable Cox regression, unmarried status was still associated with worse OS (HR, 1.28; 95% CI, 1.19-1.38; P < 0.001) and CSS (HR, 1.25; 95% CI, 1.15-1.36; P < 0.001). In summary, unmarried status is associated with poorer survival in PTCL, underscoring the need to incorporate psychosocial support into personalized care strategies for socially vulnerable populations.

Related

  1. A multicentre phase III clinical trial of dual-epigenetic therapy plus CHOP compared with CHOP in previously untreated patients with peripheral T-cell lymphoma.
    Chong Wei, Liping Su, Xiaobo Wang +9
    Blood cancer journalPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMCDOAJ
  2. Peripheral Nerve Conduction Abnormalities and Their Association with Clinical Outcomes in Patients with Unilateral Hemiplegia Secondary to Stroke
    Selen Özgözen, Pınar Doruk Analan
    Journal of Clinical MedicinePeer-reviewedCC BY 4.0General medicineCrossref
  3. Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report
    Kohei Kiso, Yusuke Shimoyama, Saki Okuda-Hiwatashi +11
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textGeneral medicineJ-STAGE
  4. Clinical Characteristics, Progression of Disease Within 24 Months (POD24), and Real-World Outcomes of Follicular Lymphoma in Saudi Arabia: A Two-Centre Retrospective Analysis
    Mubarak Al-Mansour, Abdulrahman Salah Alharbi, Hadi Abdulhadi Sirdar +6
    CancersPeer-reviewedCC BY 4.0Full textOncologyCrossrefEurope PMC
  5. Clinical phenotypes and outcomes of spinal cord stimulation in painful peripheral polyneuropathy: a cohort including diabetic, chemotherapy-induced, and idiopathic etiologies.
    Ángeles Canós, Beatriz Castel, Ara Bermejo +6
    Frontiers in pain research (Lausanne, Switzerland)Peer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC

Cite

BibTeXRIS
BibTeX
@article{luo2026influence,
  title = {{Influence of marital status on clinical outcomes in peripheral T-cell lymphoma: a population-based analysis.}},
  author = {Gengcong Luo and Yongqing Li and Chen Wu and Hongbin Jiang and Chunjia Zhang and Xiaoling Zheng and Xitian Chen and Zhao Wang and Weilin Xia},
  journal = {Clinical and experimental medicine},
  year = {2026},
  month = jul,
  doi = {10.1007/s10238-026-02269-2},
  url = {https://europepmc.org/article/MED/42905306},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Influence of marital status on clinical outcomes in peripheral T-cell lymphoma: a population-based analysis.
AU  - Gengcong Luo
AU  - Yongqing Li
AU  - Chen Wu
AU  - Hongbin Jiang
AU  - Chunjia Zhang
AU  - Xiaoling Zheng
AU  - Xitian Chen
AU  - Zhao Wang
AU  - Weilin Xia
PY  - 2026
DA  - 2026/07/26
JO  - Clinical and experimental medicine
DO  - 10.1007/s10238-026-02269-2
UR  - https://europepmc.org/article/MED/42905306
AB  - Peripheral T-cell lymphoma (PTCL) is an aggressive malignancy with poor prognosis that requires intensive systemic therapy, highlighting the potential impact of psychosocial factors on disease management and clinical outcomes. In this population-based study using SEER data from 2013 to 2022, we identified 5,919 patients newly diagnosed with PTCL. Propensity score matching (PSM) was applied to control for baseline differences, and survival outcomes were evaluated using Kaplan-Meier analysis and Cox proportional hazards models. Unmarried patients were more likely to be female, younger, and of non-White race. Survival analysis demonstrated that unmarried patients had significantly lower 5-year overall survival (OS: 40.7% vs. 45.7%; P < 0.001) and cause-specific survival (CSS: 49.9% vs. 53.8%; P = 0.0018). This survival disparity persisted after PSM (n = 4,481), with significantly lower 5-year OS (40.0% vs. 47.9%, P < 0.001) and CSS (49.1% vs. 55.3%, P < 0.001) in unmarried patients. On multivariable Cox regression, unmarried status was still associated with worse OS (HR, 1.28; 95% CI, 1.19-1.38; P < 0.001) and CSS (HR, 1.25; 95% CI, 1.15-1.36; P < 0.001). In summary, unmarried status is associated with poorer survival in PTCL, underscoring the need to incorporate psychosocial support into personalized care strategies for socially vulnerable populations.
SN  - 1591-8890
SN  - 1591-9528
ER  -