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Peer-reviewedCC BYNature Communications

A metal-DNA biohybrid as enantioselective artificial photoDNAzyme

  • Zachary Pastorel1,2
  • Juliette Zanzi3,4
  • Mathieu Noël1,5
  • Alessio Bartocci6,7
  • Stellios Arseniyadis8,9
  • Elise E. Dumont10,4
  • Yves Canac11,4
  • Olivier Baslé12,2
  • Michaël Smietana13
13 affiliations
  1. 1Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, Montpellier, France
  2. 2Université de Montpellier
  3. 3LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France
  4. 4Université de Toulouse
  5. 5University of Trento
  6. 6Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
  7. 7Queen Mary University of London
  8. 8Department of Chemistry, Queen Mary University of London, London, UK
  9. 9Institut de Chimie de Nice
  10. 10Institut de Chimie de Nice UMR 7272, Université Côte d'Azur, CNRS, Nice, France
  11. 11LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France. [email protected]
  12. 12LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France. [email protected]
  13. 13Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, Montpellier, France. [email protected]
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Abstract

Visible light photocatalysis, which exploits the reactivity of molecules at their excited state, has triggered a paradigm shift in organic synthesis by enabling some very unique chemical transformations. Yet, achieving precise control of the enantioselectivity in such processes remains a major challenge. A promising strategy involves linking a synthetic transition metal photocatalyst within the chiral architecture of a biomolecule to create a highly selective artificial metallo-photoenzyme. However, such an artificial metalloenzyme that integrates the merits of biocatalysis and photocatalysis to promote abiological reactions with high enantioselectivity is still unknown. Here, we report an artificial metallo-photoDNAzyme resulting from the covalent anchoring of a visible light-absorbing iridium-based photocatalyst within a double-stranded (ds)DNA helix, exhibiting efficient triplet-triplet energy transfer and high levels of enantioselectivity in [2 + 2] intramolecular cycloadditions.

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Cite

BibTeXRIS
BibTeX
@article{pastorel2026metaldna,
  title = {{A metal-DNA biohybrid as enantioselective artificial photoDNAzyme}},
  author = {Zachary Pastorel and Juliette Zanzi and Mathieu Noël and Alessio Bartocci and Stellios Arseniyadis and Elise E. Dumont and Yves Canac and Olivier Baslé and Michaël Smietana},
  journal = {Nature Communications},
  year = {2026},
  month = may,
  doi = {10.1038/s41467-026-72881-z},
  url = {https://doi.org/10.1038/s41467-026-72881-z},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A metal-DNA biohybrid as enantioselective artificial photoDNAzyme
AU  - Zachary Pastorel
AU  - Juliette Zanzi
AU  - Mathieu Noël
AU  - Alessio Bartocci
AU  - Stellios Arseniyadis
AU  - Elise E. Dumont
AU  - Yves Canac
AU  - Olivier Baslé
AU  - Michaël Smietana
PY  - 2026
DA  - 2026/05/13
JO  - Nature Communications
DO  - 10.1038/s41467-026-72881-z
UR  - https://doi.org/10.1038/s41467-026-72881-z
AB  - Visible light photocatalysis, which exploits the reactivity of molecules at their excited state, has triggered a paradigm shift in organic synthesis by enabling some very unique chemical transformations. Yet, achieving precise control of the enantioselectivity in such processes remains a major challenge. A promising strategy involves linking a synthetic transition metal photocatalyst within the chiral architecture of a biomolecule to create a highly selective artificial metallo-photoenzyme. However, such an artificial metalloenzyme that integrates the merits of biocatalysis and photocatalysis to promote abiological reactions with high enantioselectivity is still unknown. Here, we report an artificial metallo-photoDNAzyme resulting from the covalent anchoring of a visible light-absorbing iridium-based photocatalyst within a double-stranded (ds)DNA helix, exhibiting efficient triplet-triplet energy transfer and high levels of enantioselectivity in [2 + 2] intramolecular cycloadditions.
SN  - 2041-1723
ER  -