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Peer-reviewedLicence not statedNature Biotechnology

A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells

  • Sami Nourreddine1
  • Yesh Doctor1
  • Amir Dailamy1
  • Antoine Forget2,3
  • Yi-Hung Lee1
  • Rebecca Chinn1,4
  • Hammza Khaliq1
  • Benjamin J. Polacco5,2,3
  • Monita Muralidharan2,3
  • Emily Pan1
  • Yifan Zhang1
  • Alina Sigaeva6
11 more authors
  • Jan N. Hansen7
  • Jiahao Gao4
  • Jillian A. Parker4
  • Kirsten Obernier5,2
  • Timothy Clark8
  • Jake Y. Chen9
  • Christian Metallo1,10
  • Emma K. Lundberg7,11
  • Trey Ideker1,4
  • Nevan Krogan12,5,2,3
  • Prashant Mali1
12 affiliations
  1. 1Department of Bioengineering, University of California San Diego, CA, USA
  2. 2Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA
  3. 3Quantitative Biosciences Institute (QBI), University of California San Francisco, CA, USA
  4. 4School of Medicine, University of California San Diego, CA, USA
  5. 5Department of Cellular and Molecular Pharmacology, University of California San Francisco, CA, USA
  6. 6Division of Cellular and Clinical Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
  7. 7Department of Bioengineering, Stanford University, CA, USA
  8. 8Department of Medicine, University of Virginia, VA, USA
  9. 9Department of Computer Science, The University of Alabama at Birmingham, VA, USA
  10. 10Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, CA, USA
  11. 11Department of Pathology, Stanford University, CA, USA
  12. 12Department of Bioengineering and Therapeutics Sciences, University of California San Francisco, CA, USA
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{nourreddine2026genomescale,
  title = {{A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells}},
  author = {Sami Nourreddine and Yesh Doctor and Amir Dailamy and Antoine Forget and Yi-Hung Lee and Rebecca Chinn and Hammza Khaliq and Benjamin J. Polacco and Monita Muralidharan and Emily Pan and Yifan Zhang and Alina Sigaeva and Jan N. Hansen and Jiahao Gao and Jillian A. Parker and Kirsten Obernier and Timothy Clark and Jake Y. Chen and Christian Metallo and Emma K. Lundberg and Trey Ideker and Nevan Krogan and Prashant Mali},
  journal = {Nature Biotechnology},
  year = {2026},
  month = jul,
  doi = {10.1038/s41587-026-03199-w},
  url = {https://doi.org/10.1101/2024.11.03.621734},
}
RIS
TY  - JOUR
TI  - A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells
AU  - Sami Nourreddine
AU  - Yesh Doctor
AU  - Amir Dailamy
AU  - Antoine Forget
AU  - Yi-Hung Lee
AU  - Rebecca Chinn
AU  - Hammza Khaliq
AU  - Benjamin J. Polacco
AU  - Monita Muralidharan
AU  - Emily Pan
AU  - Yifan Zhang
AU  - Alina Sigaeva
AU  - Jan N. Hansen
AU  - Jiahao Gao
AU  - Jillian A. Parker
AU  - Kirsten Obernier
AU  - Timothy Clark
AU  - Jake Y. Chen
AU  - Christian Metallo
AU  - Emma K. Lundberg
AU  - Trey Ideker
AU  - Nevan Krogan
AU  - Prashant Mali
PY  - 2026
DA  - 2026/07/01
JO  - Nature Biotechnology
DO  - 10.1038/s41587-026-03199-w
UR  - https://doi.org/10.1101/2024.11.03.621734
SN  - 0733-222X
SN  - 1087-0156
SN  - 1546-1696
SN  - 2331-3684
ER  -