Oral Antioxidant Provides Adjunctive Therapeutic Benefits Alongside Dexamethasone in a Rat Model of Endotoxin-Induced Uveitis.
- 1Department of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Abstract
Background
Several antioxidant combinations are commercially available; however, it remains unclear whether these combinations can enhance the anti-inflammatory effects of systemic corticosteroids in acute uveitis models.Objectives
To evaluate the anti-inflammatory and antioxidant effects of an orally administered antioxidant formulation in a lipopolysaccharide-induced uveitis rat model and explore its potential as an adjunctive therapy to corticosteroid treatment.Methods
Seventy-five male Sprague-Dawley rats were randomly and evenly assigned to five groups and orally treated for 10 days with antioxidant formulations, either alone or in combination with intravenous dexamethasone. Uveitis was induced via subcutaneous lipopolysaccharide injection. Clinical severity was assessed using a slit-lamp biomicroscope. Subsequently, a subset of five randomly selected rats per group underwent biochemical analyses of the aqueous humour and histopathological evaluation of the ocular tissues.Results
The lipopolysaccharide-treated group exhibited the highest clinical score, which was significantly reduced by dexamethasone monotherapy and combination treatment. Moreover, the antioxidant formulation significantly reduced inflammatory cell infiltration in the aqueous humour, which was further diminished by the combination treatment. TNF-α and IL-6 levels decreased upon combination therapy, yielding significantly lower TNF-α levels than those with dexamethasone monotherapy. Combination treatment significantly increased IL-10 levels. Moreover, total superoxide dismutase activity was highest in the combination group. No significant differences were observed in the histopathological scores or total protein concentrations between the dexamethasone and combination groups.Conclusions
Co-administration of dexamethasone and an antioxidant is a potential adjunctive therapeutic strategy for mitigating oxidative tissue damage.
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BibTeX
@article{yang2026oral,
title = {{Oral Antioxidant Provides Adjunctive Therapeutic Benefits Alongside Dexamethasone in a Rat Model of Endotoxin-Induced Uveitis.}},
author = {Su-Jung Yang and Joon-Young Kim},
journal = {Veterinary medicine and science},
year = {2026},
month = oct,
doi = {10.1002/vms3.71287},
url = {https://europepmc.org/article/MED/42911616},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Oral Antioxidant Provides Adjunctive Therapeutic Benefits Alongside Dexamethasone in a Rat Model of Endotoxin-Induced Uveitis.
AU - Su-Jung Yang
AU - Joon-Young Kim
PY - 2026
DA - 2026/10/30
JO - Veterinary medicine and science
DO - 10.1002/vms3.71287
UR - https://europepmc.org/article/MED/42911616
AB - Background Several antioxidant combinations are commercially available; however, it remains unclear whether these combinations can enhance the anti-inflammatory effects of systemic corticosteroids in acute uveitis models.Objectives To evaluate the anti-inflammatory and antioxidant effects of an orally administered antioxidant formulation in a lipopolysaccharide-induced uveitis rat model and explore its potential as an adjunctive therapy to corticosteroid treatment.Methods Seventy-five male Sprague-Dawley rats were randomly and evenly assigned to five groups and orally treated for 10 days with antioxidant formulations, either alone or in combination with intravenous dexamethasone. Uveitis was induced via subcutaneous lipopolysaccharide injection. Clinical severity was assessed using a slit-lamp biomicroscope. Subsequently, a subset of five randomly selected rats per group underwent biochemical analyses of the aqueous humour and histopathological evaluation of the ocular tissues.Results The lipopolysaccharide-treated group exhibited the highest clinical score, which was significantly reduced by dexamethasone monotherapy and combination treatment. Moreover, the antioxidant formulation significantly reduced inflammatory cell infiltration in the aqueous humour, which was further diminished by the combination treatment. TNF-α and IL-6 levels decreased upon combination therapy, yielding significantly lower TNF-α levels than those with dexamethasone monotherapy. Combination treatment significantly increased IL-10 levels. Moreover, total superoxide dismutase activity was highest in the combination group. No significant differences were observed in the histopathological scores or total protein concentrations between the dexamethasone and combination groups.Conclusions Co-administration of dexamethasone and an antioxidant is a potential adjunctive therapeutic strategy for mitigating oxidative tissue damage.
SN - 2053-1095
ER -