Individualized, parcel-guided rTMS to the left dorsolateral prefrontal cortex for treatment resistant depression
- 1Research and Development, Soterix Medical
Abstract
Efficacy of Transcranial Magnetic Stimulation (TMS) for depression has been shown to correlate with the proximity of stimulation to the region of LDLPFC most anti-correlated with subgenual anterior cingulate cortex (sgACC). Using the Human Connectome Project (HCP) surface-based reconstruction from a structural MRI, we observed that the region of DLPFC most anti-correlated with sgACC falls in anterior parcel 46 and encompasses the junction between adjacent parcels. Individual parcel mapped TMS directed at this target showed high efficacy for treatment resistant depression in a group of 15 patients. Pre-treatment anti-correlation between DLPFC (parcel 46) and sgACC correlated significantly with treatment response. These findings, along with our prior study, demonstrate the feasibility of individual, parcel-guided rTMS and suggest response/remission rates similar to those observed using individualized fMRI localization of the peak anti-correlated region.
Related
- Proximity to an SGC–DLPFC individualized functional target and electric-field modeling do not predict clinical outcomes of rTMS for treatment-resistant depression
- Lurasidone Induced Amphibian Like Buccal Oscillations: A Rare Case of Early Onset Tardive Dyskinesia Like Disorder in a Geriatric Patient with Treatment-Resistant Depression
- Single Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression
- The Antidepressant Effects of the mGlu2/3 Receptor Antagonist TS-161 in Treatment-Resistant Depression
- Attenuated GlycoRNA-microglial transcriptional coupling in the dorsolateral prefrontal cortex of patients with major depressive disorder: an exploratory interaction-based in-silico analysis
BibTeX
@misc{berman2026individualized,
title = {{Individualized, parcel-guided rTMS to the left dorsolateral prefrontal cortex for treatment resistant depression}},
author = {J. Berman and D. Q. Truong and A. Murphy and R. Mejia and Y. Z. Valter and A. Datta and D. C. Javitt},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.03.26362155},
url = {https://www.medrxiv.org/content/10.64898/2026.09.03.26362155v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Individualized, parcel-guided rTMS to the left dorsolateral prefrontal cortex for treatment resistant depression
AU - J. Berman
AU - D. Q. Truong
AU - A. Murphy
AU - R. Mejia
AU - Y. Z. Valter
AU - A. Datta
AU - D. C. Javitt
PY - 2026
DA - 2026/09/03
PB - medRxiv
DO - 10.64898/2026.09.03.26362155
UR - https://www.medrxiv.org/content/10.64898/2026.09.03.26362155v1
AB - Efficacy of Transcranial Magnetic Stimulation (TMS) for depression has been shown to correlate with the proximity of stimulation to the region of LDLPFC most anti-correlated with subgenual anterior cingulate cortex (sgACC). Using the Human Connectome Project (HCP) surface-based reconstruction from a structural MRI, we observed that the region of DLPFC most anti-correlated with sgACC falls in anterior parcel 46 and encompasses the junction between adjacent parcels. Individual parcel mapped TMS directed at this target showed high efficacy for treatment resistant depression in a group of 15 patients. Pre-treatment anti-correlation between DLPFC (parcel 46) and sgACC correlated significantly with treatment response. These findings, along with our prior study, demonstrate the feasibility of individual, parcel-guided rTMS and suggest response/remission rates similar to those observed using individualized fMRI localization of the peak anti-correlated region.
ER -