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Peer-reviewedLicence not statedNew England Journal of Medicine

Setmelanotide for the Treatment of Acquired Hypothalamic Obesity

  • Jennifer L. Miller1
  • Hanneke Margo van Santen2,3
  • Susan A. Phillips4,5
  • Jill Hamilton6
  • Jens Aberle7
  • Thozhukat Sathyapalan8
  • Zainaba Mohamed9
  • Shana Erin McCormack10,11
  • Ashley Hall Shoemaker12
  • Megan Moriarty Kelsey13
  • Luma Mudhafar Ghalib14
  • Guenter Stalla15
21 more authors
  • Vidhu Thaker16,17
  • Reema L. Habiby18,19
  • Katie Larson Ode20
  • Martin Wabitsch21,22
  • Mehul Dattani23
  • Mary Jennifer Abuzzahab24
  • Hussein Abdullatif25
  • Ryan Morgan26
  • Margaret A. Stefater‐Richards27
  • Vanita R. Aroda28,29
  • Carsten Friedrich30
  • Joan C. Han31
  • Hiraku Ono32
  • Keisuke Nagasaki33
  • Tomohiro Tanaka34
  • Tsuyoshi Isojima35
  • Hiroshi Arima36
  • Cecilia Scimia37
  • Guojun Yuan37
  • Hermann Lothar Muller30
  • Christian Ludwig Roth38
38 affiliations
  1. 1Pediatric Endocrinology, Department of Pediatrics, College of Medicine, University of Florida, Gainesville
  2. 2Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, the Netherlands
  3. 3Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
  4. 4Department of Pediatrics, Division of Endocrinology, University of California, San Diego, San Diego
  5. 5Rady Children’s Hospital, San Diego
  6. 6Division of Endocrinology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto
  7. 7University Medical Center Hamburg–Eppendorf, Hamburg, Germany
  8. 8Hull York Medical School, Hull, United Kingdom
  9. 9Birmingham Women’s and Children’s, Birmingham, United Kingdom
  10. 10Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia
  11. 11Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Philadelphia
  12. 12Vanderbilt University Medical Center, Nashville
  13. 13Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora
  14. 14Ohio State Wexner Medical Center, Columbus
  15. 15Medicover Neuroendokrinologie Medizinisches Versorgungszentrum, Münster, Germany
  16. 16Division of Molecular Genetics, Columbia University Irving Medical Center, New York
  17. 17Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Irving Medical Center, New York
  18. 18Division of Endocrinology, Ann and Robert H. Lurie Children’s Hospital, Chicago
  19. 19Feinberg School of Medicine, Northwestern University, Chicago
  20. 20Division of Pediatric Endocrinology and Diabetes, Stead Family Department of Pediatrics, University of Iowa, Iowa City
  21. 21Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, University Hospital Ulm, Ulm, Germany
  22. 22German Center for Child and Adolescent Health (DZKJ), partner site, Ulm, Germany
  23. 23Genetics and Genomic Medicine Programme, University College London Great Ormond Street Institute of Child Health, London
  24. 24Children’s Minnesota, St. Paul
  25. 25Department of Pediatric Endocrinology, University of Alabama, Birmingham
  26. 26Lynn Health Science Institute, Oklahoma City
  27. 27Division of Endocrinology, Boston Children’s Hospital, Boston
  28. 28Brigham and Women’s Hospital, Boston
  29. 29Harvard Medical School, Boston
  30. 30University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg, Oldenburg, Germany
  31. 31Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Diabetes, Obesity, and Metabolism Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York
  32. 32Chiba University Hospital, Chiba, Japan
  33. 33Life Science Research Center, Nagano Children’s Hospital, Nagano, Japan
  34. 34Nagoya City University Hospital, Nagoya, Japan
  35. 35Department of Pediatrics, Toranomon Hospital, Tokyo
  36. 36Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
  37. 37Rhythm Pharmaceuticals, Boston
  38. 38Seattle Children’s Research Institute, Norcliffe Foundation Center for Integrative Brain Research, Department of Pediatrics, University of Washington, Seattle
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Cite

BibTeXRIS
BibTeX
@article{miller2026setmelanotide,
  title = {{Setmelanotide for the Treatment of Acquired Hypothalamic Obesity}},
  author = {Jennifer L. Miller and Hanneke Margo van Santen and Susan A. Phillips and Jill Hamilton and Jens Aberle and Thozhukat Sathyapalan and Zainaba Mohamed and Shana Erin McCormack and Ashley Hall Shoemaker and Megan Moriarty Kelsey and Luma Mudhafar Ghalib and Guenter Stalla and Vidhu Thaker and Reema L. Habiby and Katie Larson Ode and Martin Wabitsch and Mehul Dattani and Mary Jennifer Abuzzahab and Hussein Abdullatif and Ryan Morgan and Margaret A. Stefater‐Richards and Vanita R. Aroda and Carsten Friedrich and Joan C. Han and Hiraku Ono and Keisuke Nagasaki and Tomohiro Tanaka and Tsuyoshi Isojima and Hiroshi Arima and Cecilia Scimia and Guojun Yuan and Hermann Lothar Muller and Christian Ludwig Roth},
  journal = {New England Journal of Medicine},
  year = {2026},
  month = jul,
  doi = {10.1056/nejmoa2512275},
  url = {https://doi.org/10.1056/NEJMoa2512275},
}
RIS
TY  - JOUR
TI  - Setmelanotide for the Treatment of Acquired Hypothalamic Obesity
AU  - Jennifer L. Miller
AU  - Hanneke Margo van Santen
AU  - Susan A. Phillips
AU  - Jill Hamilton
AU  - Jens Aberle
AU  - Thozhukat Sathyapalan
AU  - Zainaba Mohamed
AU  - Shana Erin McCormack
AU  - Ashley Hall Shoemaker
AU  - Megan Moriarty Kelsey
AU  - Luma Mudhafar Ghalib
AU  - Guenter Stalla
AU  - Vidhu Thaker
AU  - Reema L. Habiby
AU  - Katie Larson Ode
AU  - Martin Wabitsch
AU  - Mehul Dattani
AU  - Mary Jennifer Abuzzahab
AU  - Hussein Abdullatif
AU  - Ryan Morgan
AU  - Margaret A. Stefater‐Richards
AU  - Vanita R. Aroda
AU  - Carsten Friedrich
AU  - Joan C. Han
AU  - Hiraku Ono
AU  - Keisuke Nagasaki
AU  - Tomohiro Tanaka
AU  - Tsuyoshi Isojima
AU  - Hiroshi Arima
AU  - Cecilia Scimia
AU  - Guojun Yuan
AU  - Hermann Lothar Muller
AU  - Christian Ludwig Roth
PY  - 2026
DA  - 2026/07/08
JO  - New England Journal of Medicine
DO  - 10.1056/nejmoa2512275
UR  - https://doi.org/10.1056/NEJMoa2512275
SN  - 0028-4793
SN  - 0096-6762
SN  - 1533-4406
SN  - 2331-4710
ER  -