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PreprintCC BYChemRxiv

Self-assembly of DNA-β-sheet peptide conjugates into emergent micrometer-sized rods

  • Henry W. Rose1
  • Akiko Sato2
  • Isobel Jones2
  • Emerald R. Taylor2
  • Findley R. Morgan1
  • Takeru Dannoue1
  • David M. Beal3
  • Michael R. Reithofer4
  • Christopher J. Serpell1
4 affiliations
  1. 1UCL School of Pharmacy, 29-39 Brunswick Square, London, UK, WC1N 1AX
  2. 2School of Chemistry and Forensic Science, University of Kent, Ingram Building, Canterbury, Kent, UK, CT2 7NH
  3. 3School of Biosciences, University of Kent, Stacey Building, Canterbury, Kent, UK, CT2 7NJ
  4. 4Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Wӓhringer Straße. 42, Vienna, Austria, 1090
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Abstract

Peptide-oligonucleotide conjugates can unite DNA nanotechnology with peptide self-assembly to create new and unusual nanostructures. We have created the first conjugate of DNA to a Waltz peptide – a class of β-sheet peptides which are important in the study of biological amyloids. Multi-micrometer rods have been identified which are attributable to peptide-dominated assembly. These results could lead to new ways to interface with amyloid, as well as demonstrating the range of self-assembled structures possible with DNA-peptide conjugates.

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Cite

BibTeXRIS
BibTeX
@misc{rose2026selfassembly,
  title = {{Self-assembly of DNA-β-sheet peptide conjugates into emergent micrometer-sized rods}},
  author = {Henry W. Rose and Akiko Sato and Isobel Jones and Emerald R. Taylor and Findley R. Morgan and Takeru Dannoue and David M. Beal and Michael R. Reithofer and Christopher J. Serpell},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010968/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010968/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Self-assembly of DNA-β-sheet peptide conjugates into emergent micrometer-sized rods
AU  - Henry W. Rose
AU  - Akiko Sato
AU  - Isobel Jones
AU  - Emerald R. Taylor
AU  - Findley R. Morgan
AU  - Takeru Dannoue
AU  - David M. Beal
AU  - Michael R. Reithofer
AU  - Christopher J. Serpell
PY  - 2026
DA  - 2026/10/23
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010968/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010968/v1
AB  - Peptide-oligonucleotide conjugates can unite DNA nanotechnology with peptide self-assembly to create new and unusual nanostructures. We have created the first conjugate of DNA to a Waltz peptide – a class of β-sheet peptides which are important in the study of biological amyloids. Multi-micrometer rods have been identified which are attributable to peptide-dominated assembly. These results could lead to new ways to interface with amyloid, as well as demonstrating the range of self-assembled structures possible with DNA-peptide conjugates.
ER  -