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Peer-reviewedCC BY 3.0Chemical Science

Co-assembly and self-sorting are not mutually exclusive in enantiomeric peptide systems

  • Simona Bianco1,2
  • Ravi R. Sonani3
  • Libby J. Marshall2
  • Alex S. Loch2
  • James Doutch4
  • Edward H. Egelman3
  • Dave J. Adams2
4 affiliations
  1. 1MAX IV Laboratory, Lund University Lund 224 84 Sweden
  2. 2School of Chemistry, University of Glasgow Glasgow G12 8QQ UK
  3. 3Department of Biochemistry and Molecular Genetics, University of Virginia Charlottesville VA 22903 USA
  4. 4ISIS Pulsed Neutron and Muon Source Harwell Science and Innovation Campus Didcot OX11 0QX UK
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Abstract

Co-assembly and self-sorting in multicomponent systems are typically treated as mutually exclusive outcomes. Here, we show that this distinction is incomplete. Using enantiomeric peptide nanotubes, we demonstrate that a single co-assembled structure forms only at an equimolar composition, yet remains internally self-sorted into compositionally distinct domains. Contrast-matched neutron scattering directly reveals this segregation and shows that the co-assembled structures adopt layered architectures rather than simple molecular-level mixing. These results establish that co-assembly and self-sorting can coexist within a single supramolecular object across length scales, providing a general framework for understanding and controlling multicomponent self-assembly.

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Cite

BibTeXRIS
BibTeX
@article{bianco2026coassembly,
  title = {{Co-assembly and self-sorting are not mutually exclusive in enantiomeric peptide systems}},
  author = {Simona Bianco and Ravi R. Sonani and Libby J. Marshall and Alex S. Loch and James Doutch and Edward H. Egelman and Dave J. Adams},
  journal = {Chemical Science},
  year = {2026},
  month = aug,
  doi = {10.1039/d6sc04454a},
  url = {https://doi.org/10.1039/d6sc04454a},
  note = {CC BY 3.0},
}
RIS
TY  - JOUR
TI  - Co-assembly and self-sorting are not mutually exclusive in enantiomeric peptide systems
AU  - Simona Bianco
AU  - Ravi R. Sonani
AU  - Libby J. Marshall
AU  - Alex S. Loch
AU  - James Doutch
AU  - Edward H. Egelman
AU  - Dave J. Adams
PY  - 2026
DA  - 2026/08/27
JO  - Chemical Science
DO  - 10.1039/d6sc04454a
UR  - https://doi.org/10.1039/d6sc04454a
AB  - Co-assembly and self-sorting in multicomponent systems are typically treated as mutually exclusive outcomes. Here, we show that this distinction is incomplete. Using enantiomeric peptide nanotubes, we demonstrate that a single co-assembled structure forms only at an equimolar composition, yet remains internally self-sorted into compositionally distinct domains. Contrast-matched neutron scattering directly reveals this segregation and shows that the co-assembled structures adopt layered architectures rather than simple molecular-level mixing. These results establish that co-assembly and self-sorting can coexist within a single supramolecular object across length scales, providing a general framework for understanding and controlling multicomponent self-assembly.
SN  - 2041-6520
SN  - 2041-6539
ER  -