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Peer-reviewedCC BYAppl.Radiat.Isot.

Assessment of the 49Ti(d,x) route to produce the theranostic radionuclide 47Sc based on cross-section measurements

  • Lucia de Dominicis
  • Sara Cisternino
  • Juan Esposito
  • Alisa Kotliarenko
  • Ferid Haddad
  • Etienne Nigron
  • Gaia Pupillo
  • Liliana Mou
Open at sourcePDFDOICite

Abstract

The availability of the theranostic radionuclide 47 Sc is hindered by the lack of a reliable high purity production method. The aim of this work is to evaluate a less considered pathway exploiting deuteron beams on enriched 49 Ti targets. The investigation started from the measurements of the production cross sections of the emergent radionuclide 47 Sc, as well as of the co-produced contaminants which play an important role on the final purity and in the evaluation of the dose eventually administered to a patient. Enriched 49 Ti targets, manufactured at the INFN-LNL (National Institute for Nuclear Physics-Legnaro National Laboratories), were activated in several irradiation runs carried out at the GIP ARRONAX (Group of Public Interest Accelerator for Research in Radiochemistry and Oncology in Nantes-Atlantique) facility cyclotron utilizing the tunable 15÷35 MeV deuteron beam. The obtained cross section trends, which constitute the first measurement for some radionuclides, are compared to theoretical curves and literature data, when available. The experimental cross sections are then discussed to assess 49 Ti(d,x) as a possible production route for 47 Sc. The results demonstrated that 49 Ti(d,α) 47 Sc can be considered as a valid alternative production route for the supply of this medically interesting radionuclide.

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Cite

BibTeXRIS
BibTeX
@article{dominicis2026assessment,
  title = {{Assessment of the $^49$Ti(d,x) route to produce the theranostic radionuclide $^47$Sc based on cross-section measurements}},
  author = {Lucia de Dominicis and Sara Cisternino and Juan Esposito and Alisa Kotliarenko and Ferid Haddad and Etienne Nigron and Gaia Pupillo and Liliana Mou},
  journal = {Appl.Radiat.Isot.},
  year = {2026},
  month = nov,
  doi = {10.1016/j.apradiso.2026.113047},
  url = {https://hal.science/hal-05849784v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Assessment of the ^49Ti(d,x) route to produce the theranostic radionuclide ^47Sc based on cross-section measurements
AU  - Lucia de Dominicis
AU  - Sara Cisternino
AU  - Juan Esposito
AU  - Alisa Kotliarenko
AU  - Ferid Haddad
AU  - Etienne Nigron
AU  - Gaia Pupillo
AU  - Liliana Mou
PY  - 2026
DA  - 2026/11/03
JO  - Appl.Radiat.Isot.
DO  - 10.1016/j.apradiso.2026.113047
UR  - https://hal.science/hal-05849784v1
AB  - The availability of the theranostic radionuclide 47 Sc is hindered by the lack of a reliable high purity production method. The aim of this work is to evaluate a less considered pathway exploiting deuteron beams on enriched 49 Ti targets. The investigation started from the measurements of the production cross sections of the emergent radionuclide 47 Sc, as well as of the co-produced contaminants which play an important role on the final purity and in the evaluation of the dose eventually administered to a patient. Enriched 49 Ti targets, manufactured at the INFN-LNL (National Institute for Nuclear Physics-Legnaro National Laboratories), were activated in several irradiation runs carried out at the GIP ARRONAX (Group of Public Interest Accelerator for Research in Radiochemistry and Oncology in Nantes-Atlantique) facility cyclotron utilizing the tunable 15÷35 MeV deuteron beam. The obtained cross section trends, which constitute the first measurement for some radionuclides, are compared to theoretical curves and literature data, when available. The experimental cross sections are then discussed to assess 49 Ti(d,x) as a possible production route for 47 Sc. The results demonstrated that 49 Ti(d,α) 47 Sc can be considered as a valid alternative production route for the supply of this medically interesting radionuclide.
ER  -