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Peer-reviewedCC BYScientific Reports

Application of ultra-widefield scanning laser ophthalmoscopy in early familial exudative vitreoretinopathy

  • Fei Yuan1
  • Hui Wang1
  • Qin Wang1
  • Feng Wang1
  • Yan Bai1
  • In-chul Jeon2
  • Chanjuan Wang3
  1. 1Ophthalmology Center, Changzhi People’s Hospital Affiliated to Changzhi Medical College
  2. 2College of Health and Welfare, Dongshin University
  3. 3Ningxia Eye Hospital, People’s Hospital of Ningxia Hui Autonomous Region
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Abstract

This study aimed to evaluate the screening value and diagnostic performance of ultra-widefield scanning laser ophthalmoscopy (UWF-SLO) in early familial exudative vitreoretinopathy (FEVR) in asymptomatic first-degree relatives of affected patients, using fundus fluorescein angiography (FFA) as the reference standard. This retrospective cross-sectional diagnostic accuracy study included 68 asymptomatic first-degree relatives (136 eyes in total) confirmed as carriers of FEVR-causative genes via genetic testing. All subjects underwent both UWF-SLO and FFA examinations during the same period. Using FFA as the reference standard, we assessed the diagnostic agreement, sensitivity, and specificity of UWF-SLO. UWF-SLO detected at least one fundus abnormality in 92.6% (126/136) of eyes, while FFA did so in 95.6% (130/136). UWF-SLO detected vitreoretinal interface abnormalities (67.6%) and pigmentation within avascular areas (39.7%) that FFA could not reliably visualize. Using FFA as the reference standard, UWF-SLO demonstrated a sensitivity of 93.8% (95% CI: 88.2%–97.3%; 87.5%–98.5% by participant-clustered bootstrap) and a specificity of 33.3% (95% CI: 4.3%–77.7%; 0.0%–100.0% by participant-clustered bootstrap). The specificity estimate is based on only 6 FFA-negative eyes and should be interpreted with caution for diagnosing FEVR. UWF-SLO is a promising adjunctive non-invasive imaging modality for detecting FFA-defined peripheral abnormalities in genetically confirmed relatives at high risk for FEVR. It offers particular advantages in identifying structural fundus abnormalities and can serve as an effective complement to FFA.

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Cite

BibTeXRIS
BibTeX
@article{yuan2026application,
  title = {{Application of ultra-widefield scanning laser ophthalmoscopy in early familial exudative vitreoretinopathy}},
  author = {Fei Yuan and Hui Wang and Qin Wang and Feng Wang and Yan Bai and In-chul Jeon and Chanjuan Wang},
  journal = {Scientific Reports},
  year = {2026},
  month = aug,
  doi = {10.1038/s41598-026-67631-6},
  url = {https://doi.org/10.1038/s41598-026-67631-6},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Application of ultra-widefield scanning laser ophthalmoscopy in early familial exudative vitreoretinopathy
AU  - Fei Yuan
AU  - Hui Wang
AU  - Qin Wang
AU  - Feng Wang
AU  - Yan Bai
AU  - In-chul Jeon
AU  - Chanjuan Wang
PY  - 2026
DA  - 2026/08/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-67631-6
UR  - https://doi.org/10.1038/s41598-026-67631-6
AB  - This study aimed to evaluate the screening value and diagnostic performance of ultra-widefield scanning laser ophthalmoscopy (UWF-SLO) in early familial exudative vitreoretinopathy (FEVR) in asymptomatic first-degree relatives of affected patients, using fundus fluorescein angiography (FFA) as the reference standard. This retrospective cross-sectional diagnostic accuracy study included 68 asymptomatic first-degree relatives (136 eyes in total) confirmed as carriers of FEVR-causative genes via genetic testing. All subjects underwent both UWF-SLO and FFA examinations during the same period. Using FFA as the reference standard, we assessed the diagnostic agreement, sensitivity, and specificity of UWF-SLO. UWF-SLO detected at least one fundus abnormality in 92.6% (126/136) of eyes, while FFA did so in 95.6% (130/136). UWF-SLO detected vitreoretinal interface abnormalities (67.6%) and pigmentation within avascular areas (39.7%) that FFA could not reliably visualize. Using FFA as the reference standard, UWF-SLO demonstrated a sensitivity of 93.8% (95% CI: 88.2%–97.3%; 87.5%–98.5% by participant-clustered bootstrap) and a specificity of 33.3% (95% CI: 4.3%–77.7%; 0.0%–100.0% by participant-clustered bootstrap). The specificity estimate is based on only 6 FFA-negative eyes and should be interpreted with caution for diagnosing FEVR. UWF-SLO is a promising adjunctive non-invasive imaging modality for detecting FFA-defined peripheral abnormalities in genetically confirmed relatives at high risk for FEVR. It offers particular advantages in identifying structural fundus abnormalities and can serve as an effective complement to FFA.
SN  - 2045-2322
ER  -