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Peer-reviewedCC BYScientific Reports

Curcumin promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-206/Hdac4 signaling axis

  • Yu Liu1
  • Zhitao Zhang1
  • Qianwen Tang1
  • Yongyun Lian1
  • Chuang Sun1
  • Zhiyuan Lu1
  1. 1Department of Orthopedics, Fourth Affiliated Hospital of Harbin Medical University
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Abstract

Osteoporosis is characterized by an imbalance between osteoblast-mediated bone formation and osteoclast-driven bone resorption, where decreased osteogenic differentiation coupled with excessive osteoclastic activity leads to progressive bone loss and microarchitectural deterioration. This study investigated the regulatory effects of curcumin on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying molecular mechanisms. Collectively, our data establish that curcumin exerts its pro-osteogenic effects via the miR-206/Hdac4 signaling cascade, providing mechanistic insight into its potential in vitro bone-protective properties. Our experimental data further demonstrate that curcumin treatment significantly upregulates miR-206 expression while downregulating Hdac4 levels in BMSCs, resulting in enhanced osteogenic differentiation capacity. The optimal concentration of curcumin was determined using CCK-8 assays. Subsequent mechanistic investigations through Western blot and quantitative real-time PCR analyses elucidated the regulatory relationship between curcumin and the miR-206/Hdac4 signaling axis. Functional validation via alkaline phosphatase staining and alizarin red S mineralization assays supported that curcumin promoted osteogenic activity and mineralization potential of BMSCs. This study suggests that curcumin promotes osteogenic differentiation of BMSCs in vitro and may have potential relevance for bone biology through the miR-206/Hdac4 signaling axis.

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Cite

BibTeXRIS
BibTeX
@article{liu2026curcumin,
  title = {{Curcumin promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-206/Hdac4 signaling axis}},
  author = {Yu Liu and Zhitao Zhang and Qianwen Tang and Yongyun Lian and Chuang Sun and Zhiyuan Lu},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-62653-6},
  url = {https://doi.org/10.1038/s41598-026-62653-6},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Curcumin promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-206/Hdac4 signaling axis
AU  - Yu Liu
AU  - Zhitao Zhang
AU  - Qianwen Tang
AU  - Yongyun Lian
AU  - Chuang Sun
AU  - Zhiyuan Lu
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-62653-6
UR  - https://doi.org/10.1038/s41598-026-62653-6
AB  - Osteoporosis is characterized by an imbalance between osteoblast-mediated bone formation and osteoclast-driven bone resorption, where decreased osteogenic differentiation coupled with excessive osteoclastic activity leads to progressive bone loss and microarchitectural deterioration. This study investigated the regulatory effects of curcumin on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying molecular mechanisms. Collectively, our data establish that curcumin exerts its pro-osteogenic effects via the miR-206/Hdac4 signaling cascade, providing mechanistic insight into its potential in vitro bone-protective properties. Our experimental data further demonstrate that curcumin treatment significantly upregulates miR-206 expression while downregulating Hdac4 levels in BMSCs, resulting in enhanced osteogenic differentiation capacity. The optimal concentration of curcumin was determined using CCK-8 assays. Subsequent mechanistic investigations through Western blot and quantitative real-time PCR analyses elucidated the regulatory relationship between curcumin and the miR-206/Hdac4 signaling axis. Functional validation via alkaline phosphatase staining and alizarin red S mineralization assays supported that curcumin promoted osteogenic activity and mineralization potential of BMSCs. This study suggests that curcumin promotes osteogenic differentiation of BMSCs in vitro and may have potential relevance for bone biology through the miR-206/Hdac4 signaling axis.
SN  - 2045-2322
ER  -