Nodular Pulmonary Sarcoidosis with a B-cell Reaction Similar to That of IgG4-related Disease

Abstract

A 66-year-old man presented to our hospital following the detection of abnormal chest shadows during a previous medical checkup. Chest computed tomography revealed multiple small nodules in both lungs, and surgical biopsy was performed for the diagnosis. A histological examination of the pulmonary nodules revealed small non-caseating epithelioid cell granulomas with prominent infiltration of lymphocytes and IgG4-positive plasma cells. The patient was eventually diagnosed with pulmonary sarcoidosis, with a B-cell response similar to that of IgG4-related disease. This report provides insight into sarcoidosis with histopathological features similar to those of IgG4-related diseases.

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BibTeX RIS

BibTeX

@article{tokuyasu2026nodular,
  title = {{Nodular Pulmonary Sarcoidosis with a B-cell Reaction Similar to That of IgG4-related Disease}},
  author = {Hirokazu Tokuyasu and Shuichi Matsuoka and Katsunori Arai and Hiromitsu Sakai and Ken Miwa and Chika Esumi and Akira Yamasaki},
  journal = {Internal Medicine},
  year = {2026},
  month = jul,
  doi = {10.2169/internalmedicine.6009-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6009-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Nodular Pulmonary Sarcoidosis with a B-cell Reaction Similar to That of IgG4-related Disease
AU  - Hirokazu Tokuyasu
AU  - Shuichi Matsuoka
AU  - Katsunori Arai
AU  - Hiromitsu Sakai
AU  - Ken Miwa
AU  - Chika Esumi
AU  - Akira Yamasaki
PY  - 2026
DA  - 2026/07/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6009-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6009-25/_article
AB  - A 66-year-old man presented to our hospital following the detection of abnormal chest shadows during a previous medical checkup. Chest computed tomography revealed multiple small nodules in both lungs, and surgical biopsy was performed for the diagnosis. A histological examination of the pulmonary nodules revealed small non-caseating epithelioid cell granulomas with prominent infiltration of lymphocytes and IgG4-positive plasma cells. The patient was eventually diagnosed with pulmonary sarcoidosis, with a B-cell response similar to that of IgG4-related disease. This report provides insight into sarcoidosis with histopathological features similar to those of IgG4-related diseases.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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