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Peer-reviewedCC BY 4.0Respirology Case Reports

Pulmonary Sarcoidosis Presenting as a Solitary Pulmonary Nodule With Probable Neurosarcoidosis: A Case Report

  • Mai Homochi1
  • Toshihiro Shirai2
  • Toyohiro Sato3
  • Aya Mukai4
  • Tatsuya Tanaka4
  • Fumitaka Hashiba4
  • Ayako Masaki5
  • Aya Naiki‐Ito6
  • Osamu Takakuwa7
  • Yoshihiro Kanemitsu4
7 affiliations
  1. 1Department of Education and Training Shizuoka General Hospital Shizuoka Japan
  2. 2Department of Respiratory Medicine Shizuoka General Hospital Shizuoka Japan
  3. 3Department of Neurology and Neuroscience Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan
  4. 4Department of Respiratory Medicine, Allergy, and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan
  5. 5Department of Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan
  6. 6Department of Experimental Pathology and Tumor Biology Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan
  7. 7Department of Medical Education Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan
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Abstract

A 51‐year‐old woman presented with a solitary pulmonary nodule, hilar and mediastinal lymphadenopathy and progressive sensory disturbances. FDG‐PET demonstrated intense uptake in the pulmonary and hilar lesions, while spinal MRI showed thoracic cord enhancement. Lung cancer‐associated paraneoplastic neurological syndrome was initially suspected. Biopsies of the endobronchial lesion and a mediastinal lymph node revealed noncaseating granulomas without malignancy. Ocular involvement and neurological findings supported pulmonary sarcoidosis with probable neurosarcoidosis. Corticosteroid therapy improved neurological symptoms. Long‐term follow‐up showed a stable pulmonary nodule and sustained neurological improvement. This case highlights the importance of tissue diagnosis and careful neurological assessment when pulmonary nodules and sensory disturbances suggest malignancy.

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Cite

BibTeXRIS
BibTeX
@article{homochi2026pulmonary,
  title = {{Pulmonary Sarcoidosis Presenting as a Solitary Pulmonary Nodule With Probable Neurosarcoidosis: A Case Report}},
  author = {Mai Homochi and Toshihiro Shirai and Toyohiro Sato and Aya Mukai and Tatsuya Tanaka and Fumitaka Hashiba and Ayako Masaki and Aya Naiki‐Ito and Osamu Takakuwa and Yoshihiro Kanemitsu},
  journal = {Respirology Case Reports},
  year = {2026},
  month = nov,
  doi = {10.1002/rcr2.70814},
  url = {https://doi.org/10.1002/rcr2.70814},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Pulmonary Sarcoidosis Presenting as a Solitary Pulmonary Nodule With Probable Neurosarcoidosis: A Case Report
AU  - Mai Homochi
AU  - Toshihiro Shirai
AU  - Toyohiro Sato
AU  - Aya Mukai
AU  - Tatsuya Tanaka
AU  - Fumitaka Hashiba
AU  - Ayako Masaki
AU  - Aya Naiki‐Ito
AU  - Osamu Takakuwa
AU  - Yoshihiro Kanemitsu
PY  - 2026
DA  - 2026/11/03
JO  - Respirology Case Reports
DO  - 10.1002/rcr2.70814
UR  - https://doi.org/10.1002/rcr2.70814
AB  - A 51‐year‐old woman presented with a solitary pulmonary nodule, hilar and mediastinal lymphadenopathy and progressive sensory disturbances. FDG‐PET demonstrated intense uptake in the pulmonary and hilar lesions, while spinal MRI showed thoracic cord enhancement. Lung cancer‐associated paraneoplastic neurological syndrome was initially suspected. Biopsies of the endobronchial lesion and a mediastinal lymph node revealed noncaseating granulomas without malignancy. Ocular involvement and neurological findings supported pulmonary sarcoidosis with probable neurosarcoidosis. Corticosteroid therapy improved neurological symptoms. Long‐term follow‐up showed a stable pulmonary nodule and sustained neurological improvement. This case highlights the importance of tissue diagnosis and careful neurological assessment when pulmonary nodules and sensory disturbances suggest malignancy.
SN  - 2051-3380
ER  -