Diabetic Striatopathy Following Radiological Improvement: An Autopsy-confirmed Case Report and Literature Review
Abstract
Diabetic striatopathy (DS) is a rare neurological complication in poorly controlled diabetes mellitus. The pathogenesis of DS is thought to involve microvascular injury; however, autopsy-based histological documentation remains scarce. We report an autopsy-confirmed case of DS complicated by right cerebellar hemorrhagic infarction, in which hemichorea developed despite radiological improvement. A histological examination showed neuronal loss, reactive astrocytosis, calcification, and organizing hemorrhage with fibroblast proliferation in the basal ganglia within 82 days after the initial imaging. These findings highlight the paradox between radiological normalization and irreversible pathological injury, supporting DS as a spectrum that extends from functional disturbance to structural damage.
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BibTeX
@article{ando2026diabetic,
title = {{Diabetic Striatopathy Following Radiological Improvement: An Autopsy-confirmed Case Report and Literature Review}},
author = {Yuya Ando and Masato Kadoya and Ayumu Kurihara and Ayano Matsunaga and Ayako Mikoshi and Hiroaki Takeo and Tsutomu Kodera},
journal = {Internal Medicine},
year = {2026},
month = nov,
doi = {10.2169/internalmedicine.6470-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6470-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Diabetic Striatopathy Following Radiological Improvement: An Autopsy-confirmed Case Report and Literature Review
AU - Yuya Ando
AU - Masato Kadoya
AU - Ayumu Kurihara
AU - Ayano Matsunaga
AU - Ayako Mikoshi
AU - Hiroaki Takeo
AU - Tsutomu Kodera
PY - 2026
DA - 2026/11/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.6470-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6470-25/_article
AB - Diabetic striatopathy (DS) is a rare neurological complication in poorly controlled diabetes mellitus. The pathogenesis of DS is thought to involve microvascular injury; however, autopsy-based histological documentation remains scarce. We report an autopsy-confirmed case of DS complicated by right cerebellar hemorrhagic infarction, in which hemichorea developed despite radiological improvement. A histological examination showed neuronal loss, reactive astrocytosis, calcification, and organizing hemorrhage with fibroblast proliferation in the basal ganglia within 82 days after the initial imaging. These findings highlight the paradox between radiological normalization and irreversible pathological injury, supporting DS as a spectrum that extends from functional disturbance to structural damage.
SN - 1349-7235
SN - 0918-2918
ER -