The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration
Abstract
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration.
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BibTeX
@article{hernandezhernandez2026myogenic,
title = {{The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration}},
author = {J. Manuel Hernández-Hernández and Estela García-González and Caroline E. Brun and Michael Rudnicki},
journal = {Seminars in Cell and Developmental Biology},
year = {2026},
month = sep,
doi = {10.1016/j.semcdb.2017.11.010},
url = {https://hal.science/hal-05747709v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration
AU - J. Manuel Hernández-Hernández
AU - Estela García-González
AU - Caroline E. Brun
AU - Michael Rudnicki
PY - 2026
DA - 2026/09/12
JO - Seminars in Cell and Developmental Biology
DO - 10.1016/j.semcdb.2017.11.010
UR - https://hal.science/hal-05747709v1
AB - The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration.
SN - 1084-9521
SN - 1096-3634
ER -