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Peer-reviewedCC BYTrends in Genetics

The fungal RIP hypermutator mechanism has deep eukaryotic roots

  • Fabienne Malagnac
  • Eugene Gladyshev
  • Daniel Croll
  • Thomas Badet
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Abstract

The repeat-induced point mutation (RIP) targets repeated sequences, such as transposable elements, in filamentous fungi. Host-transposable element coevolutionary dynamics have shaped taxonomically restricted eukaryotic defense systems, likely built on conserved ancestral mechanisms. Key questions surrounding homology recognition remain unresolved, and RIP offers a unique opportunity to answer them.

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Cite

BibTeXRIS
BibTeX
@article{malagnac2026fungal,
  title = {{The fungal RIP hypermutator mechanism has deep eukaryotic roots}},
  author = {Fabienne Malagnac and Eugene Gladyshev and Daniel Croll and Thomas Badet},
  journal = {Trends in Genetics},
  year = {2026},
  month = oct,
  doi = {10.1016/j.tig.2026.05.008},
  url = {https://hal.science/hal-05802482v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The fungal RIP hypermutator mechanism has deep eukaryotic roots
AU  - Fabienne Malagnac
AU  - Eugene Gladyshev
AU  - Daniel Croll
AU  - Thomas Badet
PY  - 2026
DA  - 2026/10/16
JO  - Trends in Genetics
DO  - 10.1016/j.tig.2026.05.008
UR  - https://hal.science/hal-05802482v1
AB  - The repeat-induced point mutation (RIP) targets repeated sequences, such as transposable elements, in filamentous fungi. Host-transposable element coevolutionary dynamics have shaped taxonomically restricted eukaryotic defense systems, likely built on conserved ancestral mechanisms. Key questions surrounding homology recognition remain unresolved, and RIP offers a unique opportunity to answer them.
SN  - 0168-9525
SN  - 1362-4555
ER  -