Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality ― The Hisayama Study ―
Abstract
BACKGROUND: Few epidemiological studies have investigated the association between changes in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and mortality in the general Asian population. METHODS AND RESULTS: We followed 2,703 community-dwelling Japanese residents aged ≥40 years who had serum NT-proBNP concentrations measured in both 2002-2003 and 2007-2008 over a median period of 10.3 years. Changes in NT-proBNP were categorized as decreasing (change ≤-25%), no change (-25%<change<+25%), or increasing (change ≥+25%). Mortality hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. During the follow-up period, 497 deaths occurred (108 cardiovascular, 389 non-cardiovascular). Compared with the no-change group, multivariable-adjusted HRs in the increasing group were 1.73 (95% CI 1.37-2.17), 1.76 (95% CI 1.08-2.87), and 1.71 (95% CI 1.32-2.22) for all-cause, cardiovascular, and non-cardiovascular mortality, respectively. Subgroup analyses by baseline serum NT-proBNP concentration (2002-2003) showed consistent associations with all-cause mortality in both lower (<125 pg/mL) and higher (≥125 pg/mL) NT-proBNP groups, with a tendency towards stronger associations in the higher NT-proBNP group. CONCLUSIONS: Changes in serum NT-proBNP concentrations may indicate mortality risk in a community-dwelling Asian population.
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BibTeX
@article{kato2026association,
title = {{Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality ― The Hisayama Study ―}},
author = {Asahi Kato and Emi Oishi and Akihiro Maezono and Satoko Sakata and Yoshihiko Furuta and Mao Shibata and Jun Hata and Tetsuro Ago and Kohtaro Abe and Toshiharu Ninomiya},
journal = {Circulation Journal},
year = {2026},
month = sep,
doi = {10.1253/circj.cj-25-1168},
url = {https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1168/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality ― The Hisayama Study ―
AU - Asahi Kato
AU - Emi Oishi
AU - Akihiro Maezono
AU - Satoko Sakata
AU - Yoshihiko Furuta
AU - Mao Shibata
AU - Jun Hata
AU - Tetsuro Ago
AU - Kohtaro Abe
AU - Toshiharu Ninomiya
PY - 2026
DA - 2026/09/25
JO - Circulation Journal
DO - 10.1253/circj.cj-25-1168
UR - https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1168/_article
AB - BACKGROUND: Few epidemiological studies have investigated the association between changes in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and mortality in the general Asian population. METHODS AND RESULTS: We followed 2,703 community-dwelling Japanese residents aged ≥40 years who had serum NT-proBNP concentrations measured in both 2002-2003 and 2007-2008 over a median period of 10.3 years. Changes in NT-proBNP were categorized as decreasing (change ≤-25%), no change (-25%<change<+25%), or increasing (change ≥+25%). Mortality hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. During the follow-up period, 497 deaths occurred (108 cardiovascular, 389 non-cardiovascular). Compared with the no-change group, multivariable-adjusted HRs in the increasing group were 1.73 (95% CI 1.37-2.17), 1.76 (95% CI 1.08-2.87), and 1.71 (95% CI 1.32-2.22) for all-cause, cardiovascular, and non-cardiovascular mortality, respectively. Subgroup analyses by baseline serum NT-proBNP concentration (2002-2003) showed consistent associations with all-cause mortality in both lower (<125 pg/mL) and higher (≥125 pg/mL) NT-proBNP groups, with a tendency towards stronger associations in the higher NT-proBNP group. CONCLUSIONS: Changes in serum NT-proBNP concentrations may indicate mortality risk in a community-dwelling Asian population.
SN - 1347-4820
SN - 1346-9843
ER -