Mapping the global work-related impact of immune-mediated inflammatory skin diseases: a systematic review
Abstract
Immune-mediated inflammatory diseases (IMIDs) of the skin can significantly affect individuals' work functioning and pose societal challenges. This systematic review examined the burden of common skin IMIDs (alopecia areata, atopic dermatitis, hidradenitis suppurativa, psoriasis, vitiligo) on work outcomes. Eight databases (PubMed, Web of Science Core Collection, Embase, SciELO, KCI Korean Journal Database, Global Index Medicus, Informit, and Google Scholar) were searched through June 2024. Eligible studies included adults with one of these IMIDs and quantitative designs (trials, cohorts, case-control or cross-sectional) reporting work outcomes. From 8,176 records, 196 studies were included. Sample sizes ranged from small (n=28) to nationwide datasets (n=2,638,681). Psoriasis (56.12%) and atopic dermatitis (31.12%) dominated, mainly from Europe (54.08%). Most studies (92.35%) assessed productivity and predominantly reported validated tools. Evidence shows that skin IMIDs affect multiple work domains, extending beyond productivity loss to psychosocial factors, such as burnout or employment status. Heterogeneity in measurement methods limits external validity. Research gaps persist for rarer IMIDs and low to-middle-income settings, particularly sub-Saharan Africa (only 0.51%). Evidence indicates a substantial effect of skin IMIDs on work, yet consensus on work-related outcomes is lacking. Greater conceptual clarity is needed to understand their impact on employment and support sustainable work participation.
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BibTeX
@article{kpenou2026mapping,
title = {{Mapping the global work-related impact of immune-mediated inflammatory skin diseases: a systematic review}},
author = {Fanny Kpenou and Ju Hee Han and Marc Fadel and Tat-Thang Vo and Hyun Jeong Ju and Tarik El Aarbaoui and Christopher E.M. Griffiths and Henry Lim and Lars French and Carsten Flohr and Suzanne Keddie and Rosa Parisi and Gregor B.E. Jemec and Jennifer Kilmer and Darren Ashcroft and Maria Hordinsky and Viktoria Eleftheriadou and Esther Freeman and L. Claire Fuller and Jung Min Bae and Viet-Thi Tran and Alexis Descatha and Khaled Ezzedine},
journal = {Journal of Investigative Dermatology},
year = {2026},
month = jul,
doi = {10.1016/j.jid.2026.07.017},
url = {https://ehesp.hal.science/hal-05722340v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Mapping the global work-related impact of immune-mediated inflammatory skin diseases: a systematic review
AU - Fanny Kpenou
AU - Ju Hee Han
AU - Marc Fadel
AU - Tat-Thang Vo
AU - Hyun Jeong Ju
AU - Tarik El Aarbaoui
AU - Christopher E.M. Griffiths
AU - Henry Lim
AU - Lars French
AU - Carsten Flohr
AU - Suzanne Keddie
AU - Rosa Parisi
AU - Gregor B.E. Jemec
AU - Jennifer Kilmer
AU - Darren Ashcroft
AU - Maria Hordinsky
AU - Viktoria Eleftheriadou
AU - Esther Freeman
AU - L. Claire Fuller
AU - Jung Min Bae
AU - Viet-Thi Tran
AU - Alexis Descatha
AU - Khaled Ezzedine
PY - 2026
DA - 2026/07/30
JO - Journal of Investigative Dermatology
DO - 10.1016/j.jid.2026.07.017
UR - https://ehesp.hal.science/hal-05722340v1
AB - Immune-mediated inflammatory diseases (IMIDs) of the skin can significantly affect individuals' work functioning and pose societal challenges. This systematic review examined the burden of common skin IMIDs (alopecia areata, atopic dermatitis, hidradenitis suppurativa, psoriasis, vitiligo) on work outcomes. Eight databases (PubMed, Web of Science Core Collection, Embase, SciELO, KCI Korean Journal Database, Global Index Medicus, Informit, and Google Scholar) were searched through June 2024. Eligible studies included adults with one of these IMIDs and quantitative designs (trials, cohorts, case-control or cross-sectional) reporting work outcomes. From 8,176 records, 196 studies were included. Sample sizes ranged from small (n=28) to nationwide datasets (n=2,638,681). Psoriasis (56.12%) and atopic dermatitis (31.12%) dominated, mainly from Europe (54.08%). Most studies (92.35%) assessed productivity and predominantly reported validated tools. Evidence shows that skin IMIDs affect multiple work domains, extending beyond productivity loss to psychosocial factors, such as burnout or employment status. Heterogeneity in measurement methods limits external validity. Research gaps persist for rarer IMIDs and low to-middle-income settings, particularly sub-Saharan Africa (only 0.51%). Evidence indicates a substantial effect of skin IMIDs on work, yet consensus on work-related outcomes is lacking. Greater conceptual clarity is needed to understand their impact on employment and support sustainable work participation.
SN - 0022-202X
SN - 1523-1747
ER -