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Peer-reviewedCC BY 4.0Cells

Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium

  • Françoise Pirson1,2,3
  • Esmeralda Fraille Lopez4,5
  • Cloé Hupin2,3,6,7
  • Carine Sohy3,8,9
  • Bertrand Bearzatto2,10
  • Marylène Lecocq2,3
  • Charles Pilette1,2,3
10 affiliations
  1. 1Department of Pulmonary Medicine, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium
  2. 2Allergy Center Saint-Luc, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium
  3. 3Lung, Nose and Skin Research Unit (LUNS), Institute of Experimental and Clinical Research (IREC), Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium
  4. 4Faculty of Medicine, Campus of Woluwé-Saint-Lambert, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium
  5. 5Dispens′s Soins, 6200 Châtelet, Belgium
  6. 6Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium
  7. 7Department of Otgorhinolaryngology, Hôpital Delta, 1160 Brussels, Belgium
  8. 8Department of Pulmonary Medicine, University Hospital Center UCL Namur, Godinne Site, 5530 Yvoir, Belgium
  9. 9Allergy Center Godinne, University Hospital Center UCL Namur, Godinne Site, 5330 Yvoir, Belgium
  10. 10Experimental and Clinical Research Institute (IREC), Center for Applied Molecular Technologies, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium
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Abstract

Birch pollen-sensitized patients co-sensitized to Bet v 1 and Bet v 2 allergens present more frequent and severe respiratory or plant-related food allergy symptoms (PFASs). This study analyzed the relevance of Bet v 1 and profilin sensitization in the clinical phenotype of pollen-allergic patients in Belgium. Ten patients allergic to birch pollen (BPA), 31 to grass pollen (GPA) and 33 to both pollens (MPA), with rhino-conjunctivitis with/without asthma (ARRC), were evaluated by means of questionnaire, skin-prick tests and specific IgE assays. Half of GPA were co-sensitized to birch pollen, and no BPA were sensitized to profilin. The prevalence of asthma and pollen-related food allergy syndrome (PFAS) was higher in BPA than in MPA or GPA, with a higher severity of PFAS in asthmatic BPA. GPA with PFAS were more frequently sensitized to Bet v 1, with higher levels of rBet v 1-IgE. The prevalence of PFAS, together with the duration of rhinitis and PFAS tended to increase in profilin-polysensitized vs. mono- and un-sensitized GPA, regardless of Bet v 1-IgE and the severity of symptoms.

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Cite

BibTeXRIS
BibTeX
@article{pirson2026allergen,
  title = {{Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium}},
  author = {Françoise Pirson and Esmeralda Fraille Lopez and Cloé Hupin and Carine Sohy and Bertrand Bearzatto and Marylène Lecocq and Charles Pilette},
  journal = {Cells},
  year = {2026},
  month = oct,
  doi = {10.3390/cells15201907},
  url = {https://www.mdpi.com/2073-4409/15/20/1907},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium
AU  - Françoise Pirson
AU  - Esmeralda Fraille Lopez
AU  - Cloé Hupin
AU  - Carine Sohy
AU  - Bertrand Bearzatto
AU  - Marylène Lecocq
AU  - Charles Pilette
PY  - 2026
DA  - 2026/10/20
JO  - Cells
DO  - 10.3390/cells15201907
UR  - https://www.mdpi.com/2073-4409/15/20/1907
AB  - Birch pollen-sensitized patients co-sensitized to Bet v 1 and Bet v 2 allergens present more frequent and severe respiratory or plant-related food allergy symptoms (PFASs). This study analyzed the relevance of Bet v 1 and profilin sensitization in the clinical phenotype of pollen-allergic patients in Belgium. Ten patients allergic to birch pollen (BPA), 31 to grass pollen (GPA) and 33 to both pollens (MPA), with rhino-conjunctivitis with/without asthma (ARRC), were evaluated by means of questionnaire, skin-prick tests and specific IgE assays. Half of GPA were co-sensitized to birch pollen, and no BPA were sensitized to profilin. The prevalence of asthma and pollen-related food allergy syndrome (PFAS) was higher in BPA than in MPA or GPA, with a higher severity of PFAS in asthmatic BPA. GPA with PFAS were more frequently sensitized to Bet v 1, with higher levels of rBet v 1-IgE. The prevalence of PFAS, together with the duration of rhinitis and PFAS tended to increase in profilin-polysensitized vs. mono- and un-sensitized GPA, regardless of Bet v 1-IgE and the severity of symptoms.
SN  - 2073-4409
ER  -