Clinical characteristics, infection sites, and mortality risk factors in community-acquired hypermucoviscous Klebsiella pneumoniae infections
- 1Intensive Care Unit Department, Zhongshan City People's Hospital, Guangdong Province, China
- 2Department of Respiratory Medicine, Zhongshan City People's Hospital, Guangdong Province, China
- 3Intensive Care Unit Department, Zhongshan Huangpu People's Hospital, Guangdong Province, China
Abstract
Objective: We aim to investigate the clinical, laboratory, and biological characteristics of patients with hypermucoviscous Klebsiella pneumoniae (hmKp) infections across various community settings to inform early screening of high-risk patients and improve treatment success rates.
Methods: Patients were categorized into hmKp and non-hmKp groups. We analyzed the clinical presentation, laboratory findings, infection sites, and drug-sensitivity test results of the clinical isolates to identify mortality risk factors associated with hmKp infections.
Results: The mortality rate for patients with multisite infection involving the lungs and bloodstream was as high as 76% in hmKp group, surpassing that in the non-hmKp group, although this difference was not statistically significant (p = 0.055). Invasive infections most frequently occurred concurrently with infections of the liver, lungs, and bloodstream. The resistance and mortality rates for hmKp infection were both 17%. Notably, nearly 18% of the patients had concurrent intracranial infections, which had the highest mortality risk of 100% for hmKp. Although both hmKp and non-hmKp strains were sensitive to most antibiotics, the non-hmKp strains exhibited higher antibiotic resistance. Multivariate regression analysis identified advanced age (OR: 1.04; 95% CI: 1.01-1.08; p = 0.024) and high SOFA (OR: 1.49; 95% CI: 1.21-1.83, p = 0.000) and APACHE II scores (OR: 1.10; 95% CI: 1.00-1.20, p = 0.049) as independent mortality risk factors for patients with hmKp.
Conclusions: HmKp infections at varied anatomical locations exhibit significant prognostic differences. Invasive infections pose a particularly high mortality risk. Timely treatment escalation may improve prognosis among older patients with high SOFA and APACHE II scores.
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BibTeX
@article{sun2026clinical,
title = {{Clinical characteristics, infection sites, and mortality risk factors in community-acquired hypermucoviscous Klebsiella pneumoniae infections}},
author = {Hongkui Sun and Li Lei and Wenqing Lai and Qingbiao Liang and Miaolian Chen},
journal = {Journal of Infection in Developing Countries},
year = {2026},
month = oct,
doi = {10.3855/jidc.22340},
url = {https://doi.org/10.3855/jidc.22340},
note = {CC BY},
}
RIS
TY - JOUR
TI - Clinical characteristics, infection sites, and mortality risk factors in community-acquired hypermucoviscous Klebsiella pneumoniae infections
AU - Hongkui Sun
AU - Li Lei
AU - Wenqing Lai
AU - Qingbiao Liang
AU - Miaolian Chen
PY - 2026
DA - 2026/10/01
JO - Journal of Infection in Developing Countries
DO - 10.3855/jidc.22340
UR - https://doi.org/10.3855/jidc.22340
AB - Objective: We aim to investigate the clinical, laboratory, and biological characteristics of patients with hypermucoviscous Klebsiella pneumoniae (hmKp) infections across various community settings to inform early screening of high-risk patients and improve treatment success rates. Methods: Patients were categorized into hmKp and non-hmKp groups. We analyzed the clinical presentation, laboratory findings, infection sites, and drug-sensitivity test results of the clinical isolates to identify mortality risk factors associated with hmKp infections. Results: The mortality rate for patients with multisite infection involving the lungs and bloodstream was as high as 76% in hmKp group, surpassing that in the non-hmKp group, although this difference was not statistically significant (p = 0.055). Invasive infections most frequently occurred concurrently with infections of the liver, lungs, and bloodstream. The resistance and mortality rates for hmKp infection were both 17%. Notably, nearly 18% of the patients had concurrent intracranial infections, which had the highest mortality risk of 100% for hmKp. Although both hmKp and non-hmKp strains were sensitive to most antibiotics, the non-hmKp strains exhibited higher antibiotic resistance. Multivariate regression analysis identified advanced age (OR: 1.04; 95% CI: 1.01-1.08; p = 0.024) and high SOFA (OR: 1.49; 95% CI: 1.21-1.83, p = 0.000) and APACHE II scores (OR: 1.10; 95% CI: 1.00-1.20, p = 0.049) as independent mortality risk factors for patients with hmKp. Conclusions: HmKp infections at varied anatomical locations exhibit significant prognostic differences. Invasive infections pose a particularly high mortality risk. Timely treatment escalation may improve prognosis among older patients with high SOFA and APACHE II scores.
SN - 1972-2680
SN - 2036-6590
ER -