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Peer-reviewedCC BY-NC-NDThe Journal of organic chemistry

(Hetero)Adamantane Synthesis: A Triple Alkylation Reaction.

  • Terry McCallum1
  • Sam Rohe1
  • Mathieu Morin1
  • Hsin Yao Su1
  • Samuel W J Shields1
  • Kashif Tanveer1
  • Marius Mamone2
  • Nicolas Zindy2
  • Guillaume Chamelot2
  • Damian G Allis1
  • Aru Joy Hill1
  • Michael Drew1
  1. 1Department of Chemistry, CBN Nano Technologies, Inc. (CBNNT), OttawaK1Y 4W5, Ontario, Canada.
  2. 2Brilliant Matters , Saint-Augustin-de-DesmauresG3A 2E6, Quebec, Canada.
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Abstract

(Hetero)adamantanes containing tetrel bridgeheads (C, Si, and Ge) are useful structures in select areas of surface and materials science. The synthesis of diverse (hetero)adamantane-based molecules with interchangeable functional groups for broad applications is an area ripe for innovation. The discovery of an expedient and convergent method for the synthesis of (heteroadamantane) scaffolds is described. The convenient synthetic route proceeding via a triple alkylation reaction represents a breakthrough in accessing the adamantane molecular class. Application of this transformation to the synthesis of (hetero)adamantane-based tripods containing tetrel bridgeheads (C- and Ge-) was explored.

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Cite

BibTeXRIS
BibTeX
@article{mccallum2026heteroadamantane,
  title = {{(Hetero)Adamantane Synthesis: A Triple Alkylation Reaction.}},
  author = {Terry McCallum and Sam Rohe and Mathieu Morin and Hsin Yao Su and Samuel W J Shields and Kashif Tanveer and Marius Mamone and Nicolas Zindy and Guillaume Chamelot and Damian G Allis and Aru Joy Hill and Michael Drew},
  journal = {The Journal of organic chemistry},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.joc.6c01679},
  url = {https://europepmc.org/article/MED/42917513},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - (Hetero)Adamantane Synthesis: A Triple Alkylation Reaction.
AU  - Terry McCallum
AU  - Sam Rohe
AU  - Mathieu Morin
AU  - Hsin Yao Su
AU  - Samuel W J Shields
AU  - Kashif Tanveer
AU  - Marius Mamone
AU  - Nicolas Zindy
AU  - Guillaume Chamelot
AU  - Damian G Allis
AU  - Aru Joy Hill
AU  - Michael Drew
PY  - 2026
DA  - 2026/10/01
JO  - The Journal of organic chemistry
DO  - 10.1021/acs.joc.6c01679
UR  - https://europepmc.org/article/MED/42917513
AB  - (Hetero)adamantanes containing tetrel bridgeheads (C, Si, and Ge) are useful structures in select areas of surface and materials science. The synthesis of diverse (hetero)adamantane-based molecules with interchangeable functional groups for broad applications is an area ripe for innovation. The discovery of an expedient and convergent method for the synthesis of (heteroadamantane) scaffolds is described. The convenient synthetic route proceeding via a triple alkylation reaction represents a breakthrough in accessing the adamantane molecular class. Application of this transformation to the synthesis of (hetero)adamantane-based tripods containing tetrel bridgeheads (C- and Ge-) was explored.
SN  - 0022-3263
SN  - 1520-6904
ER  -