Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction.
- 1Syngene International Limited Biocon Park, Bommasandra IV Phase, Jigani Link Road Bangalore 560099 Karnataka India.
- 2Department of Chemistry, REVA University Kattigenahalli, Yelahanka Bangalore 560064 Karnataka India.
- 3School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus Clappana Kollam 690525 Kerala India [email protected].
Abstract
Diaryl-substituted pyrrolidine derivatives are prevalent in numerous biologically active compounds and represent important scaffolds in medicinal chemistry. However, their synthesis remains challenging due to limitations associated with direct functionalization of the pyrrolidine ring. This work describes a facile synthesis of 1,4-diaryl-substituted pyrrolidine derivatives via Ugi multicomponent coupling reaction. The strategy enables the convergent assembly of highly functionalized pyrrolidine frameworks from readily available aromatic building blocks, thereby providing an effective alternative to conventional functionalization approaches. The operational simplicity and modularity of this method offer a practical and versatile route to pyrrolidine scaffolds of relevance to both synthetic and medicinal chemistry.
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BibTeX
@article{polineni2026facile,
title = {{Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction.}},
author = {Siva Krishna Polineni and P Sathya Shanker and Tony Kurissery Anthappan and Vipin A Nair},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07669f},
url = {https://europepmc.org/article/MED/42840431},
note = {CC BY},
}
RIS
TY - JOUR
TI - Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction.
AU - Siva Krishna Polineni
AU - P Sathya Shanker
AU - Tony Kurissery Anthappan
AU - Vipin A Nair
PY - 2026
DA - 2026/10/06
JO - RSC advances
DO - 10.1039/d6ra07669f
UR - https://europepmc.org/article/MED/42840431
AB - Diaryl-substituted pyrrolidine derivatives are prevalent in numerous biologically active compounds and represent important scaffolds in medicinal chemistry. However, their synthesis remains challenging due to limitations associated with direct functionalization of the pyrrolidine ring. This work describes a facile synthesis of 1,4-diaryl-substituted pyrrolidine derivatives via Ugi multicomponent coupling reaction. The strategy enables the convergent assembly of highly functionalized pyrrolidine frameworks from readily available aromatic building blocks, thereby providing an effective alternative to conventional functionalization approaches. The operational simplicity and modularity of this method offer a practical and versatile route to pyrrolidine scaffolds of relevance to both synthetic and medicinal chemistry.
SN - 2046-2069
ER -