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Peer-reviewedCC BY 4.0Exploration

The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery

  • Junge Chen1
  • Yuxuan Liu1
  • Bozhang Xia2
  • Julien Milon Essola3
  • Xing‐Jie Liang3
  1. 1Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University Beijing P. R. China
  2. 2Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York New York USA
  3. 3CAS Key Laboratory For Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center For Nanoscience and Technology of China Beijing P. R. China
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Abstract

Wei and colleagues reported a pH‐responsive, charge‐switchable polyzwitterionic polymer carrier that achieves non‐invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenvironment to shuttle functional macromolecules across intact skin and achieve definitive systemic therapeutic outcomes.

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Cite

BibTeXRIS
BibTeX
@article{chen2026needlefree,
  title = {{The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery}},
  author = {Junge Chen and Yuxuan Liu and Bozhang Xia and Julien Milon Essola and Xing‐Jie Liang},
  journal = {Exploration},
  year = {2026},
  month = aug,
  doi = {10.1002/exp2.70214},
  url = {https://doi.org/10.1002/exp2.70214},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery
AU  - Junge Chen
AU  - Yuxuan Liu
AU  - Bozhang Xia
AU  - Julien Milon Essola
AU  - Xing‐Jie Liang
PY  - 2026
DA  - 2026/08/26
JO  - Exploration
DO  - 10.1002/exp2.70214
UR  - https://doi.org/10.1002/exp2.70214
AB  - Wei and colleagues reported a pH‐responsive, charge‐switchable polyzwitterionic polymer carrier that achieves non‐invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenvironment to shuttle functional macromolecules across intact skin and achieve definitive systemic therapeutic outcomes.
SN  - 2766-8509
SN  - 2766-2098
ER  -