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Peer-reviewedCC BY-NCRSC advances

Selective benzylic C-H electrochemical oxygenation under ambient air promoted by an Fe-N-C electrocatalyst.

  • Zeyao Liang1
  • Jiahe Zhang1
  • Zezhao Huang1
  • Li Zhu2
  • Xiaoquan Yao1
  1. 1Department of Applied Chemistry, College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China [email protected].
  2. 2Department of Chemistry, School of Pharmacy, Nanjing Medical University Nanjing 211166 China [email protected].
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Abstract

Selective benzylic C-H electrochemical oxygenation is achieved using ambient air via a cathode-loaded Fe-N-C electrocatalyst, in which Fe sites serve as the primary catalytically active species. This protocol provides a range of aromatic aldehydes and ketones in up to 96% isolated yields with broad functional group tolerance. Mechanistic studies reveal that the reaction proceeds through a superoxide radical anion (O₂˙⁻) generated at the cathode and a benzylic radical intermediate generated at the anode. Notably, this cathodic ORR-coupled anodic oxidation strategy is free from external chemical oxidants and uses ethanol as a green solvent, highlighting its advantages in sustainable electrochemical C-H functionalization.

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Cite

BibTeXRIS
BibTeX
@article{liang2026selective,
  title = {{Selective benzylic C-H electrochemical oxygenation under ambient air promoted by an Fe-N-C electrocatalyst.}},
  author = {Zeyao Liang and Jiahe Zhang and Zezhao Huang and Li Zhu and Xiaoquan Yao},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra07068j},
  url = {https://europepmc.org/article/MED/42846472},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Selective benzylic C-H electrochemical oxygenation under ambient air promoted by an Fe-N-C electrocatalyst.
AU  - Zeyao Liang
AU  - Jiahe Zhang
AU  - Zezhao Huang
AU  - Li Zhu
AU  - Xiaoquan Yao
PY  - 2026
DA  - 2026/10/07
JO  - RSC advances
DO  - 10.1039/d6ra07068j
UR  - https://europepmc.org/article/MED/42846472
AB  - Selective benzylic C-H electrochemical oxygenation is achieved using ambient air via a cathode-loaded Fe-N-C electrocatalyst, in which Fe sites serve as the primary catalytically active species. This protocol provides a range of aromatic aldehydes and ketones in up to 96% isolated yields with broad functional group tolerance. Mechanistic studies reveal that the reaction proceeds through a superoxide radical anion (O₂˙⁻) generated at the cathode and a benzylic radical intermediate generated at the anode. Notably, this cathodic ORR-coupled anodic oxidation strategy is free from external chemical oxidants and uses ethanol as a green solvent, highlighting its advantages in sustainable electrochemical C-H functionalization.
SN  - 2046-2069
ER  -