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Peer-reviewedCC BY-NC-NDClinical case reports

Potential Association of BRCA Mutation and Lymphocytic Lobulitis.

  • Parul Garg1
  • Sena Park1
  • Femi E Ayeni1,2
  • Senarath Edirimanne1,2
  1. 1Department of Surgery Nepean Hospital Kingswood New South Wales Australia.
  2. 2Nepean Clinical School Nepean Institute of Academic Surgery, The University of Sydney Kingswood New South Wales Australia.
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Abstract

Lymphocytic lobulitis (LL) is a rare fibroinflammatory breast lesion historically associated with long-standing Type 1 diabetes mellitus and autoimmune conditions. Recent evidence suggests possible links between LL and hereditary breast cancer syndromes, particularly BRCA mutations. We present the case of a BRCA1 mutation carrier who developed bilateral lymphocytic lobulitis with B-cell predominance, discuss its clinicopathologic features, and review current literature on the intersection of autoimmune, metabolic, and genetic risk pathways.

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Cite

BibTeXRIS
BibTeX
@article{garg2026potential,
  title = {{Potential Association of BRCA Mutation and Lymphocytic Lobulitis.}},
  author = {Parul Garg and Sena Park and Femi E Ayeni and Senarath Edirimanne},
  journal = {Clinical case reports},
  year = {2026},
  month = oct,
  doi = {10.1002/ccr3.73798},
  url = {https://europepmc.org/article/MED/42927254},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Potential Association of BRCA Mutation and Lymphocytic Lobulitis.
AU  - Parul Garg
AU  - Sena Park
AU  - Femi E Ayeni
AU  - Senarath Edirimanne
PY  - 2026
DA  - 2026/10/24
JO  - Clinical case reports
DO  - 10.1002/ccr3.73798
UR  - https://europepmc.org/article/MED/42927254
AB  - Lymphocytic lobulitis (LL) is a rare fibroinflammatory breast lesion historically associated with long-standing Type 1 diabetes mellitus and autoimmune conditions. Recent evidence suggests possible links between LL and hereditary breast cancer syndromes, particularly BRCA mutations. We present the case of a BRCA1 mutation carrier who developed bilateral lymphocytic lobulitis with B-cell predominance, discuss its clinicopathologic features, and review current literature on the intersection of autoimmune, metabolic, and genetic risk pathways.
SN  - 2050-0904
ER  -