Skip to content
DraconiticResearch
Search Sources API
197,578 studies31 sourcesUpdated 13 min ago
Peer-reviewedCC BYFrontiers in medicine

Prolonged infusion of meropenem for suspected intracystic infection in polycystic kidney disease during pregnancy: a case report.

  • Bingqing Ruan1
  • Danjia Xie1
  • Liangqi Yan1,2
  • Nianying Deng1,3
  1. 1Department of Internal Medicine, Wenling Maternal and Child Health Hospital, Wenling, Zhejiang, China.
  2. 2Ultrasound Room, Wenling Maternal and Child Health Hospital, Wenling, Zhejiang, China.
  3. 3Department of Pharmacy, Wenling Maternal and Child Health Hospital, Wenling, Zhejiang, China.
Read full textPDFDOICite

Abstract

Background

Intrarenal cyst infection in polycystic kidney disease (PKD) is hard to confirm and harder to treat during pregnancy, when lipid-soluble antibiotics are generally avoided.Case

A pregnant woman at approximately 10 weeks' gestation presented with recurrent fever and flank pain for over one month, with acute exacerbation one day prior to admission. Laboratory tests revealed progressively elevated C-reactive protein (CRP) levels despite repeatedly negative cultures. Serial ultrasound showed a right upper-pole renal cyst that evolved to exhibit internal septations and debris.Treatment and outcome

Cyst aspiration was avoided; meropenem 1 g every 8 h was initiated on admission and converted to prolonged infusion (1 g infused over more than 3 h) on Day 4, followed by step-down oral amoxicillin-clavulanate, for a total antimicrobial course of 32 days. Fever resolved and CRP normalized; pregnancy continued uneventfully.Conclusion

In a pregnant patient with suspected PKD cyst infection, prolonged-infusion meropenem was followed by clinical improvement. The favorable response observed supports further evaluation of this therapeutic strategy, despite the absence of microbiological confirmation.

Related

  1. Prolonged Primary Cytomegalovirus Infection in an Immunocompetent Adult Successfully Treated With Valganciclovir
    Sara K Iguchi, Shogo Shirota, Tomoki Kobayashi +1
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. Association of Postoperative Stress Hyperglycemia Ratio with Suspected Infection, Culture Positivity, Sepsis, and Septic Shock in 1408 Patients After Cranial Neurosurgery
    Dong Tang, Tianxiang Huang
    Journal of clinical medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Plasma and Serum Metagenomic Sequencing of Microbial Cell-Free Nucleic Acids for Suspected Central Nervous System Infection: A Systematic Review
    Felix Bratosin, Horia Silviu Branea, Elena Hogea
    Diagnostics (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Diagnostic performance of the dengue Ag NS1 rapid test in Peruvian adults with suspected dengue virus infection
    Lesly Rivera-Yancce, Jhanet Prado-Cárdenas, Jeel Moya-Salazar +3
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textEpidemiology & public healthCrossref
  5. Empirical Antibiotic Initiation for Suspected Early-Onset Neonatal Infection in the Setting of Maternal GBS Screening and Intrapartum Antibiotic Prophylaxis: A Single-Center Retrospective Cohort Study
    Anna Zmelonek-Znamirowska, Grzegorz Świercz, Jakub Mlodawski +2
    Medicina (Kaunas, Lithuania)Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{ruan2026prolonged,
  title = {{Prolonged infusion of meropenem for suspected intracystic infection in polycystic kidney disease during pregnancy: a case report.}},
  author = {Bingqing Ruan and Danjia Xie and Liangqi Yan and Nianying Deng},
  journal = {Frontiers in medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1856558},
  url = {https://europepmc.org/article/MED/42898205},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Prolonged infusion of meropenem for suspected intracystic infection in polycystic kidney disease during pregnancy: a case report.
AU  - Bingqing Ruan
AU  - Danjia Xie
AU  - Liangqi Yan
AU  - Nianying Deng
PY  - 2026
DA  - 2026/10/05
JO  - Frontiers in medicine
DO  - 10.3389/fmed.2026.1856558
UR  - https://europepmc.org/article/MED/42898205
AB  - Background  Intrarenal cyst infection in polycystic kidney disease (PKD) is hard to confirm and harder to treat during pregnancy, when lipid-soluble antibiotics are generally avoided.Case  A pregnant woman at approximately 10 weeks' gestation presented with recurrent fever and flank pain for over one month, with acute exacerbation one day prior to admission. Laboratory tests revealed progressively elevated C-reactive protein (CRP) levels despite repeatedly negative cultures. Serial ultrasound showed a right upper-pole renal cyst that evolved to exhibit internal septations and debris.Treatment and outcome  Cyst aspiration was avoided; meropenem 1 g every 8 h was initiated on admission and converted to prolonged infusion (1 g infused over more than 3 h) on Day 4, followed by step-down oral amoxicillin-clavulanate, for a total antimicrobial course of 32 days. Fever resolved and CRP normalized; pregnancy continued uneventfully.Conclusion  In a pregnant patient with suspected PKD cyst infection, prolonged-infusion meropenem was followed by clinical improvement. The favorable response observed supports further evaluation of this therapeutic strategy, despite the absence of microbiological confirmation.
SN  - 2296-858X
ER  -