Regional Validation of Coronary Heart Disease Risk Factors in Psoriasis: A Multicenter Study in Southern China
4 affiliations
- 1Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China
- 2Division of Dermatology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
- 3Division of Dermatology, Department of Medicine, Queen Mary Hospital, Hong Kong, China
- 4Department of Dermatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China
Abstract
Background: Psoriasis is a systemic inflammatory disorder associated with cardiovascular comorbidities. Although an association between psoriasis and coronary heart disease (CHD) has been established, data from southern Chinese populations remain limited. Objective: The purpose was to examine the factors associated with CHD in patients with psoriasis in a southern Chinese population. Methods: We conducted a multicenter, retrospective case–control study across three hospitals. This study included 56 cases (psoriasis with CHD) and 112 age-matched controls (psoriasis without CHD). The data were obtained from a pre-established psoriasis-specific database (September 2023–February 2025). Univariate analysis used binary logistic regression; multivariable conditional logistic regression accounted for the 1:2 age-matched design, with sex and smoking forced into the model. Results: In the multivariable conditional logistic regression analysis, greater body surface area (BSA) involvement (OR = 1.034, 95% CI: 1.009–1.059, p = 0.007), diabetes (OR = 4.748, 95% CI: 1.490–15.132, p = 0.008), and dyslipidemia (OR = 33.869, 95% CI: 4.549–252.136, p < 0.001) were significantly associated with CHD. Hypertension and smoking showed positive but non-significant associations. Conclusions: Greater BSA involvement, diabetes, and dyslipidemia were associated with CHD in this southern Chinese psoriasis cohort, consistent with previous international cohorts. These associations should be interpreted as cross-sectional rather than causal.
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BibTeX
@article{yao2026regional,
title = {{Regional Validation of Coronary Heart Disease Risk Factors in Psoriasis: A Multicenter Study in Southern China}},
author = {Yuying Yao and Martin Man Ho Chung and Zhengfeng Li and Yu Lan and Shaozhen Mai and Liuyu Chen and Xiaoyan Wu and Yu Zhang and Christina Sze Man Wong and Zhenying Zhang},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15218384},
url = {https://www.mdpi.com/2077-0383/15/21/8384},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Regional Validation of Coronary Heart Disease Risk Factors in Psoriasis: A Multicenter Study in Southern China
AU - Yuying Yao
AU - Martin Man Ho Chung
AU - Zhengfeng Li
AU - Yu Lan
AU - Shaozhen Mai
AU - Liuyu Chen
AU - Xiaoyan Wu
AU - Yu Zhang
AU - Christina Sze Man Wong
AU - Zhenying Zhang
PY - 2026
DA - 2026/10/28
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15218384
UR - https://www.mdpi.com/2077-0383/15/21/8384
AB - Background: Psoriasis is a systemic inflammatory disorder associated with cardiovascular comorbidities. Although an association between psoriasis and coronary heart disease (CHD) has been established, data from southern Chinese populations remain limited. Objective: The purpose was to examine the factors associated with CHD in patients with psoriasis in a southern Chinese population. Methods: We conducted a multicenter, retrospective case–control study across three hospitals. This study included 56 cases (psoriasis with CHD) and 112 age-matched controls (psoriasis without CHD). The data were obtained from a pre-established psoriasis-specific database (September 2023–February 2025). Univariate analysis used binary logistic regression; multivariable conditional logistic regression accounted for the 1:2 age-matched design, with sex and smoking forced into the model. Results: In the multivariable conditional logistic regression analysis, greater body surface area (BSA) involvement (OR = 1.034, 95% CI: 1.009–1.059, p = 0.007), diabetes (OR = 4.748, 95% CI: 1.490–15.132, p = 0.008), and dyslipidemia (OR = 33.869, 95% CI: 4.549–252.136, p < 0.001) were significantly associated with CHD. Hypertension and smoking showed positive but non-significant associations. Conclusions: Greater BSA involvement, diabetes, and dyslipidemia were associated with CHD in this southern Chinese psoriasis cohort, consistent with previous international cohorts. These associations should be interpreted as cross-sectional rather than causal.
SN - 2077-0383
ER -