Depressive Disorder in Patients with Degenerative Connective Tissue Diseases

Abstract

Objective: To look for presence of depression in patients managed with various connective tissue disease at medicine/ rheumatology department of our hospital.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Department of Medicine and Rheumatology, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Aug 2021 to May 2022.

Methodology: All the patients who were diagnosed with any degenerative connective tissue disorder by consultant medical specialist or rheumatologist were included in the study. Depressive symptoms were assessed by using the Beck Depression inventory. Factors like age, gender, presence of chronic pain and duration of illness were associated with presence of significant depression among the study participants.

Results: Out of 425 patients who were managed for connective tissue diseases in our hospital during the study period, 102(24.0%) were male while 323(76.0%) were female. Mean age of the study participants was 34.95±7.626 years. 283(66.5%) did not have significant depressive symptoms while 182(33.5%) had significant depressive symptoms. Longer duration of connective tissue disease and presence of significant chronic pain had statistically significant relationship with presence of depressive symptoms in our study participants (p-value<0.001).

Conclusion: Significant depressive symptoms were observed in considerable number of patients suffering from connective tissue diseases. Patients with longer duration of illness and those with significant chronic pain were more at risk of having depressive symptoms as compared to others.

Dermatoscopic Assessment of Nail Fold Capillary Patterns in Patients of Color with Different Autoimmune Connective Tissue Diseases.
Eman Ayesha, Sumera Hanif, Madeline Tchack +9
Dermatology practical & conceptual31 Jul 2026Peer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
The acute phase inflammatory response as a key determinant of reduced lipid-associated antioxidant defenses in Chinese patients with major depressive disorder
Tangcong Chen, Mengqi Niu, Yueyang Luo +4
Brain Behavior and Immunity28 Jul 2026Peer-reviewedLicence not statedFull text5 citedPsychiatry & mental healthOpenAlex
Case Report: Panic attacks after tirzepatide injection in two female patients with recurrent depressive disorder.
Ulrich Palm, Markus Backmund, Hubertus Himmerich
Frontiers in drug safety and regulation7 Oct 2026Peer-reviewedCC BYFull textPharmacology & toxicologyEurope PMC
Attenuated GlycoRNA-microglial transcriptional coupling in the dorsolateral prefrontal cortex of patients with major depressive disorder: an exploratory interaction-based in-silico analysis
R. Xu, Y. Zhang, M. Maes
medRxiv12 Oct 2026PreprintCC BYFull textPsychiatry & mental healthmedRxiv
Physical Comorbidity, Clinical Correlates, and Inpatient Management Burden in Hospitalized Patients With Major Depressive Disorder
Zhuo Jiang, Haining Song, Lingnan Gao +5
Alpha Psychiatry14 Oct 2026Peer-reviewedCC BY 4.0Full textEpidemiology & public healthPMC

Cite

BibTeX RIS

BibTeX

@article{awan2026depressive,
  title = {{Depressive Disorder in Patients with Degenerative Connective Tissue Diseases}},
  author = {Fahad Javed Awan and Muhammad Zahid Hussain Rana and Amna Butt and Syed Fahad Ul Hassan and Farhan Zaid and Muhammad Obaid Ullah},
  journal = {Pakistan Armed Forces Medical Journal},
  year = {2026},
  month = oct,
  doi = {10.51253/pafmj.v76i6.8798},
  url = {https://doi.org/10.51253/pafmj.v76i6.8798},
  note = {CC BY-NC},
}

RIS

TY  - JOUR
TI  - Depressive Disorder in Patients with Degenerative Connective Tissue Diseases
AU  - Fahad Javed Awan
AU  - Muhammad Zahid Hussain Rana
AU  - Amna Butt
AU  - Syed Fahad Ul Hassan
AU  - Farhan Zaid
AU  - Muhammad Obaid Ullah
PY  - 2026
DA  - 2026/10/31
JO  - Pakistan Armed Forces Medical Journal
DO  - 10.51253/pafmj.v76i6.8798
UR  - https://doi.org/10.51253/pafmj.v76i6.8798
AB  - Objective: To look for presence of depression in patients managed with various connective tissue disease at medicine/ rheumatology department of our hospital.  Study Design: Comparative cross-sectional study.  Place and Duration of Study: Department of Medicine and Rheumatology, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Aug 2021 to May 2022.  Methodology: All the patients who were diagnosed with any degenerative connective tissue disorder by consultant medical specialist or rheumatologist were included in the study. Depressive symptoms were assessed by using the Beck Depression inventory. Factors like age, gender, presence of chronic pain and duration of illness were associated with presence of significant depression among the study participants.  Results: Out of 425 patients who were managed for connective tissue diseases in our hospital during the study period, 102(24.0%) were male while 323(76.0%) were female. Mean age of the study participants was 34.95±7.626 years. 283(66.5%) did not have significant depressive symptoms while 182(33.5%) had significant depressive symptoms. Longer duration of connective tissue disease and presence of significant chronic pain had statistically significant relationship with presence of depressive symptoms in our study participants (p-value<0.001).  Conclusion: Significant depressive symptoms were observed in considerable number of patients suffering from connective tissue diseases. Patients with longer duration of illness and those with significant chronic pain were more at risk of having depressive symptoms as compared to others.
SN  - 0030-9648
SN  - 2411-8842
ER  -

Abstract

Related

Cite