Baseline neutrophil-to-lymphocyte ratio and mean corpuscular volume and their association with catheter-related bloodstream infection: a retrospective case-control study.
4 affiliations
- 1Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.
- 2Radiation Oncology Center, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fuzhou, 350212, China.
- 3Department of Clinical Research and Translation Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
- 4Nursing Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China. [email protected].
Abstract
Objective
This study aimed to investigate the association between baseline neutrophil-lymphocyte ratio (NLR), mean corpuscular volume (MCV), and Catheter-Related Bloodstream Infection (CRBSI).Methods
A retrospective case-control design was employed. The study included 27 patients diagnosed with CRBSI at the first affiliated hospital of fujian medical university, between January 2022 to December 2023, who were matched in a 1:2 ratio with 54 non-infected controls. Data were analyzed using multivariate logistic regression, receiver operating characteristic (ROC) curve analysis, and multifactor dimensionality reduction (MDR).Results
NLR was identified as an independent risk factor for CRBSI (OR = 1.088, P = 0.028), while MCV served as a protective factor (OR = 0.911, P = 0.016). ROC analysis showed that MCV had an AUC of 0.706 and NLR had an AUC of 0.635, with no statistically significant difference between the two AUCs. MDR analysis further revealed a significant interaction between MCV and NLR (P < 0.001). The high-risk combination (MCV < 91.5 fL and NLR ≥ 8.3) was associated with an increased odds of CRBSI (OR = 36). The prediction model constructed based on this interaction combination achieved an accuracy of 76.7%, with a 10/10 consistency in tenfold cross-validation.Conclusion
The interaction between elevated pre-catheterization NLR and decreased MCV may serve as complementary indicators for CRBSI risk assessment, facilitating early identification of high-risk patients and guiding the implementation of targeted preventive strategies in clinical practice.
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BibTeX
@article{song2026baseline,
title = {{Baseline neutrophil-to-lymphocyte ratio and mean corpuscular volume and their association with catheter-related bloodstream infection: a retrospective case-control study.}},
author = {Xiurong Song and Junjun Wu and Lingxia Shi and Shuna Huang and Ke Ma and Fan Yang and Liyun Lin and Qiaoxian Zhang},
journal = {BMC infectious diseases},
year = {2026},
month = aug,
doi = {10.1186/s12879-026-14225-2},
url = {https://europepmc.org/article/MED/43009818},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Baseline neutrophil-to-lymphocyte ratio and mean corpuscular volume and their association with catheter-related bloodstream infection: a retrospective case-control study.
AU - Xiurong Song
AU - Junjun Wu
AU - Lingxia Shi
AU - Shuna Huang
AU - Ke Ma
AU - Fan Yang
AU - Liyun Lin
AU - Qiaoxian Zhang
PY - 2026
DA - 2026/08/12
JO - BMC infectious diseases
DO - 10.1186/s12879-026-14225-2
UR - https://europepmc.org/article/MED/43009818
AB - Objective This study aimed to investigate the association between baseline neutrophil-lymphocyte ratio (NLR), mean corpuscular volume (MCV), and Catheter-Related Bloodstream Infection (CRBSI).Methods A retrospective case-control design was employed. The study included 27 patients diagnosed with CRBSI at the first affiliated hospital of fujian medical university, between January 2022 to December 2023, who were matched in a 1:2 ratio with 54 non-infected controls. Data were analyzed using multivariate logistic regression, receiver operating characteristic (ROC) curve analysis, and multifactor dimensionality reduction (MDR).Results NLR was identified as an independent risk factor for CRBSI (OR = 1.088, P = 0.028), while MCV served as a protective factor (OR = 0.911, P = 0.016). ROC analysis showed that MCV had an AUC of 0.706 and NLR had an AUC of 0.635, with no statistically significant difference between the two AUCs. MDR analysis further revealed a significant interaction between MCV and NLR (P < 0.001). The high-risk combination (MCV < 91.5 fL and NLR ≥ 8.3) was associated with an increased odds of CRBSI (OR = 36). The prediction model constructed based on this interaction combination achieved an accuracy of 76.7%, with a 10/10 consistency in tenfold cross-validation.Conclusion The interaction between elevated pre-catheterization NLR and decreased MCV may serve as complementary indicators for CRBSI risk assessment, facilitating early identification of high-risk patients and guiding the implementation of targeted preventive strategies in clinical practice.
SN - 1471-2334
ER -