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Peer-reviewedCC BYRSC advances

Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential

  • Tommaso A. Salamone1,2
  • Rosanna Mosetti3,4
  • Annalisa D'Arco4
  • Stefano Lupi4
  • Francesca Petronella5
  • Arianna Avitabile6
  • Flaminia Pompeo6
  • Luciano De Sio6
  • Sofia Marotta1
  • Stella Mrmić1
  • Beatrice Pennacchi2
  • Sara Cerra2
6 more authors
  • Souren Grigorian7
  • Michael Paulus8
  • Maurizio Alimandi1
  • Pankaj Trivedi9
  • Eleni Anastasiadou1
  • Ilaria Fratoddi2
9 affiliations
  1. 1Department of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy
  2. 2Department of Chemistry, Sapienza University of Rome Rome 00185 Italy
  3. 3Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome 00161 Rome Italy
  4. 4Department of Physics, Sapienza University of Rome Rome 00185 Italy
  5. 5National Research Council, Department of Chemical Sciences and Materials Technologies, Institute of Crystallography Montelibretti 00010 Italy
  6. 6Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Latina 04100 Italy
  7. 7Institute of Physics, University of Siegen Siegen D-57068 Germany
  8. 8Fakultät Physik/DELTA, Technische Universität Dortmund 44221 Dortmund Germany
  9. 9Department of Experimental Medicine, Sapienza University of Rome Rome 00161 Italy
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Abstract

Small-sized gold nanoparticles (AuNPs) functionalised with hydrophilic thiols were investigated. Sodium 3-mercapto-1-sulfonate and 2-(diethylamino)ethanethiol hydrochloride were used as stabilising agents in a wet synthesis approach to provide a stable colloidal system. AuNPs were loaded with the antibody trastuzumab (TZ) to evaluate the potential use of the system for photothermal-assisted controlled drug release. Furthermore, to gain a deeper understanding of the chemical interactions occurring at the interface between TZ and the surface thiols of the nanoparticles, FT-IR studies were performed both in the solid state and in suspension, suggesting a strong interaction between the surface thiols and the amidic functional groups of TZ. The photothermal (PT) behaviour of the pristine AuNPs was investigated under continuous-wave laser irradiation at 532 nm, matching the plasmon resonance band of the gold nanoparticles, resulting in an up to 20 °C temperature increase. FT-IR measurements were also carried out after laser irradiation to evaluate the potential for a controlled release of TZ from the nanoparticle surface, suggesting that light irradiation can trigger the release of the drug from the AuNPs surface, with no detrimental effect from the temperature increase. Finally, SAXS studies enabled the investigation of TZ loading and release kinetics via in situ studies over 3 hours. This work provided a detailed investigation of the interfacial chemical interactions, also giving a dual potential application of the hybrid, evaluating its use for PT therapy and for PT-assisted controlled release of the antibody.

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Cite

BibTeXRIS
BibTeX
@article{salamone2026mixedthiol,
  title = {{Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential}},
  author = {Tommaso A. Salamone and Rosanna Mosetti and Annalisa D'Arco and Stefano Lupi and Francesca Petronella and Arianna Avitabile and Flaminia Pompeo and Luciano De Sio and Sofia Marotta and Stella Mrmić and Beatrice Pennacchi and Sara Cerra and Souren Grigorian and Michael Paulus and Maurizio Alimandi and Pankaj Trivedi and Eleni Anastasiadou and Ilaria Fratoddi},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra07147c},
  url = {https://europepmc.org/article/PMC/PMC13667367},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential
AU  - Tommaso A. Salamone
AU  - Rosanna Mosetti
AU  - Annalisa D'Arco
AU  - Stefano Lupi
AU  - Francesca Petronella
AU  - Arianna Avitabile
AU  - Flaminia Pompeo
AU  - Luciano De Sio
AU  - Sofia Marotta
AU  - Stella Mrmić
AU  - Beatrice Pennacchi
AU  - Sara Cerra
AU  - Souren Grigorian
AU  - Michael Paulus
AU  - Maurizio Alimandi
AU  - Pankaj Trivedi
AU  - Eleni Anastasiadou
AU  - Ilaria Fratoddi
PY  - 2026
DA  - 2026/10/14
JO  - RSC advances
DO  - 10.1039/d6ra07147c
UR  - https://europepmc.org/article/PMC/PMC13667367
AB  - Small-sized gold nanoparticles (AuNPs) functionalised with hydrophilic thiols were investigated. Sodium 3-mercapto-1-sulfonate and 2-(diethylamino)ethanethiol hydrochloride were used as stabilising agents in a wet synthesis approach to provide a stable colloidal system. AuNPs were loaded with the antibody trastuzumab (TZ) to evaluate the potential use of the system for photothermal-assisted controlled drug release. Furthermore, to gain a deeper understanding of the chemical interactions occurring at the interface between TZ and the surface thiols of the nanoparticles, FT-IR studies were performed both in the solid state and in suspension, suggesting a strong interaction between the surface thiols and the amidic functional groups of TZ. The photothermal (PT) behaviour of the pristine AuNPs was investigated under continuous-wave laser irradiation at 532 nm, matching the plasmon resonance band of the gold nanoparticles, resulting in an up to 20 °C temperature increase. FT-IR measurements were also carried out after laser irradiation to evaluate the potential for a controlled release of TZ from the nanoparticle surface, suggesting that light irradiation can trigger the release of the drug from the AuNPs surface, with no detrimental effect from the temperature increase. Finally, SAXS studies enabled the investigation of TZ loading and release kinetics via in situ studies over 3 hours. This work provided a detailed investigation of the interfacial chemical interactions, also giving a dual potential application of the hybrid, evaluating its use for PT therapy and for PT-assisted controlled release of the antibody.
SN  - 2046-2069
ER  -