Peer-reviewedCC BYApplied Radiation and Isotopes
Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
Abstract
2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.
Related
- Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential
- 本科生综合实验：基于卤键有机框架材料的分散固相萃取方法构建及在溴代阻燃剂分析中的应用 A comprehensive undergraduate experiment： development of a dispersive solid-phase extraction method based on halogen-bonded organic frameworks and its application to the analysis of brominated flame retardants
- Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography
- Stem cell-assisted aligned electrospun nanofiber scaffold for tissue engineering: development to application.
- Development, Validation, and Application of a Highly Sensitive RP-HPLC Method for the Determination and Release Profile Comparison of Levonorgestrel from Silicone-Based Contraceptive Implants
BibTeX
@article{morris2026development,
title = {{Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide}},
author = {Olivia Morris and J. Gregory and M. Kadirvel and Fiona Henderson and A. Blykers and Adam Mcmahon and Mark Taylor and David Allsop and Stuart Allan and J. Grigg and Herve Boutin and Christian Prenant},
journal = {Applied Radiation and Isotopes},
year = {2026},
month = oct,
doi = {10.1016/j.apradiso.2016.07.023},
url = {https://hal.science/hal-05789835v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
AU - Olivia Morris
AU - J. Gregory
AU - M. Kadirvel
AU - Fiona Henderson
AU - A. Blykers
AU - Adam Mcmahon
AU - Mark Taylor
AU - David Allsop
AU - Stuart Allan
AU - J. Grigg
AU - Herve Boutin
AU - Christian Prenant
PY - 2026
DA - 2026/10/09
JO - Applied Radiation and Isotopes
DO - 10.1016/j.apradiso.2016.07.023
UR - https://hal.science/hal-05789835v1
AB - 2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.
SN - 0969-8043
SN - 1872-9800
ER -