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PreprintCC BY-NC-NDbioRxiv

Spontaneous eye behavior is an objective marker of parkinsonian severity

  • A. K. Verma
  • B. Nandakumar
  • Q. V. Feragen
  • K. Acedillo
  • N. Hjelle
  • C. M. Hendrix
  • K. Duffy
  • M. Fiecas
  • Y. Yu
  • B. Mohanty
  • J. Wang
  • J. L. Vitek
1 more authors
  • L. A. Johnson1
  1. 1Department of Neurology, University of Minnesota, Minneapolis, MN, USA
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Abstract

Eye behavior disruption is reported in Parkinson's disease (PD), but its correlation with disease severity has not been well examined. Here, in a nonhuman primate model of PD, we show that spontaneous eye behavior is impaired in parkinsonism and correlates with clinical rating scores and subthalamic beta oscillatory activity. These findings suggest that spontaneous eye behavior could serve as an objective, non-invasive biomarker of parkinsonian severity.

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Cite

BibTeXRIS
BibTeX
@misc{verma2026spontaneous,
  title = {{Spontaneous eye behavior is an objective marker of parkinsonian severity}},
  author = {A. K. Verma and B. Nandakumar and Q. V. Feragen and K. Acedillo and N. Hjelle and C. M. Hendrix and K. Duffy and M. Fiecas and Y. Yu and B. Mohanty and J. Wang and J. L. Vitek and L. A. Johnson},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.24.754183},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.24.754183v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Spontaneous eye behavior is an objective marker of parkinsonian severity
AU  - A. K. Verma
AU  - B. Nandakumar
AU  - Q. V. Feragen
AU  - K. Acedillo
AU  - N. Hjelle
AU  - C. M. Hendrix
AU  - K. Duffy
AU  - M. Fiecas
AU  - Y. Yu
AU  - B. Mohanty
AU  - J. Wang
AU  - J. L. Vitek
AU  - L. A. Johnson
PY  - 2026
DA  - 2026/09/24
PB  - bioRxiv
DO  - 10.64898/2026.09.24.754183
UR  - https://www.biorxiv.org/content/10.64898/2026.09.24.754183v1
AB  - Eye behavior disruption is reported in Parkinson's disease (PD), but its correlation with disease severity has not been well examined. Here, in a nonhuman primate model of PD, we show that spontaneous eye behavior is impaired in parkinsonism and correlates with clinical rating scores and subthalamic beta oscillatory activity. These findings suggest that spontaneous eye behavior could serve as an objective, non-invasive biomarker of parkinsonian severity.
ER  -