Stable, High-Charge, Laser-Driven VHEE Beams for Preclinical Applications
Abstract
Laser-driven plasma accelerators (LPAs) are promising sources of very-high-energy-electron (VHEE) beams for medical applications, but increasing charge per pulse while maintaining pointing stability remains challenging. We demonstrate laser-accelerated beams with total charge per pulse reaching (559 ± 56) pC using an 80 TW laser system. The spectra have a dominant component at 40-60 MeV and a high-energy tail extending to approximately 200 MeV. Pointing jitter measured in air at the irradiation target plane reaches as low as 0.7 mrad. The beams were used for VHEE irradiation experiments involving a 10 mm region of interest through a 40 mm depth at 400 ± 20 mGy/pulse. Spectral reproducibility is quantified over fixed-setting shot sequences. Particle-in-cell simulations produce a peak-and-tail spectrum through acceleration in successive bubbles associated with a strongly modified plasma wake, providing a plausible mechanism for maintaining substantial accelerated charge despite strong beam loading. Dose-weighted time-of-flight calculations indicate an effective pulse dose rate of 1012 Gy/s and average dose rates of tens of Gy/min. These results establish an LPA operating regime relevant to preclinical VHEE irradiation.
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BibTeX
@misc{varma2026stable,
title = {{Stable, High-Charge, Laser-Driven VHEE Beams for Preclinical Applications}},
author = {Chaitanya Varma and Camilla Giaccaglia and Julien Gautier and Jean-Philippe Goddet and Amar Tafzi and Pascal Rousseau and Alessandro Flacco},
howpublished = {arXiv},
year = {2026},
month = nov,
doi = {10.48550/arxiv.2611.09329},
eprint = {2611.09329},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2611.09329},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Stable, High-Charge, Laser-Driven VHEE Beams for Preclinical Applications
AU - Chaitanya Varma
AU - Camilla Giaccaglia
AU - Julien Gautier
AU - Jean-Philippe Goddet
AU - Amar Tafzi
AU - Pascal Rousseau
AU - Alessandro Flacco
PY - 2026
DA - 2026/11/06
PB - arXiv
DO - 10.48550/arxiv.2611.09329
UR - https://arxiv.org/abs/2611.09329
AB - Laser-driven plasma accelerators (LPAs) are promising sources of very-high-energy-electron (VHEE) beams for medical applications, but increasing charge per pulse while maintaining pointing stability remains challenging. We demonstrate laser-accelerated beams with total charge per pulse reaching (559 ± 56) pC using an 80 TW laser system. The spectra have a dominant component at 40-60 MeV and a high-energy tail extending to approximately 200 MeV. Pointing jitter measured in air at the irradiation target plane reaches as low as 0.7 mrad. The beams were used for VHEE irradiation experiments involving a 10 mm region of interest through a 40 mm depth at 400 ± 20 mGy/pulse. Spectral reproducibility is quantified over fixed-setting shot sequences. Particle-in-cell simulations produce a peak-and-tail spectrum through acceleration in successive bubbles associated with a strongly modified plasma wake, providing a plausible mechanism for maintaining substantial accelerated charge despite strong beam loading. Dose-weighted time-of-flight calculations indicate an effective pulse dose rate of 10^12 Gy/s and average dose rates of tens of Gy/min. These results establish an LPA operating regime relevant to preclinical VHEE irradiation.
ER -