Mechanistic insights into viral-host interactions during transcription.
- 1Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.
- 2State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Abstract
Viral transcription strategies vary significantly depending on the nature of the viral genome and the site of transcription within the host cell. A common challenge for all viruses is to circumvent host defense mechanisms while simultaneously exploiting host cellular machinery to facilitate their own transcription. DNA viruses and retroviruses often hijack the host's RNA polymerase II (Pol II), while RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRp). Through these diverse mechanisms, viruses effectively manipulate host transcription, translation, and immune responses, thereby evading immune surveillance and completing their replication cycle. This article systematically reviews the transcription strategies employed by major DNA and RNA virus families, providing insights that contribute to a deeper understanding of viral transcriptional regulation mechanisms.
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BibTeX
@article{huang2026mechanistic,
title = {{Mechanistic insights into viral-host interactions during transcription.}},
author = {Zehong Huang and Tingyu Peng and Zirui Li and Guoliang Zhu and Zixiang Zhu},
journal = {Biophysics reports},
year = {2026},
month = oct,
doi = {10.52601/bpr.2026.250066},
url = {https://europepmc.org/article/MED/42997148},
note = {CC BY},
}
RIS
TY - JOUR
TI - Mechanistic insights into viral-host interactions during transcription.
AU - Zehong Huang
AU - Tingyu Peng
AU - Zirui Li
AU - Guoliang Zhu
AU - Zixiang Zhu
PY - 2026
DA - 2026/10/31
JO - Biophysics reports
DO - 10.52601/bpr.2026.250066
UR - https://europepmc.org/article/MED/42997148
AB - Viral transcription strategies vary significantly depending on the nature of the viral genome and the site of transcription within the host cell. A common challenge for all viruses is to circumvent host defense mechanisms while simultaneously exploiting host cellular machinery to facilitate their own transcription. DNA viruses and retroviruses often hijack the host's RNA polymerase II (Pol II), while RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRp). Through these diverse mechanisms, viruses effectively manipulate host transcription, translation, and immune responses, thereby evading immune surveillance and completing their replication cycle. This article systematically reviews the transcription strategies employed by major DNA and RNA virus families, providing insights that contribute to a deeper understanding of viral transcriptional regulation mechanisms.
SN - 2364-3439
SN - 2364-3420
ER -