Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study.
8 affiliations
- 1Oncology, Faculty of Health Medicine, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. [email protected].
- 2Oncology, Faculty of Health Medicine, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
- 3Department of Oncology, Kuopio University Hospital, Kuopio, Finland.
- 4Medaffcon Oy, Espoo, Finland.
- 5Department of Oncology, Department of Radiotherapy, Kuopio University Hospital, Kuopio, Finland.
- 6Cancer Centre, Oulu University Hospital, Oulu, Finland.
- 7Takeda Oy, Helsinki, Finland.
- 8Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Abstract
Hodgkin lymphoma (HL) is a B-cell neoplasm with a cure rate of 90%. Previous data on late morbidity in patients with HL cover the era of older treatment modalities. This real-world study consisted of 2912 patients diagnosed with HL between 2000 and 2019 in Finland and aimed to clarify the incidence of late-onset cardiopulmonary morbidity compared to matched controls. Patient data were collected from four nationwide Finnish healthcare registries. We reported a higher occurrence of coronary artery disease in patients aged < 50 years at diagnosis than in controls (RR 3.80 (2.16-6.74), p < 0001). Additionally, a higher incidence of both heart failure (RR 1.68 (1.28-2.21), p < 0.001) and valvular heart disease (RR 1.80 (1.17-2.78), p = 0.006) was detected in patients aged ≥ 50 years at diagnosis than in the controls. Remarkably, in the < 50 years age group, the incidences of pneumonia (RR 4.89 (3.58-6.71), p < 0.001) and pulmonary embolism (RR 7.78 (2.75-21.95), p < 0.001) were higher than those in the control group. In conclusion, with the current treatment modalities, late cardiopulmonary morbidity in long-term survivors remains a great challenge. A strategy for primary prevention and early detection of late toxicity remains crucial and a critical evaluation of current treatment practices is warranted.
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BibTeX
@article{hannuksela2026late,
title = {{Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study.}},
author = {Noora Hannuksela and Outi Kuittinen and Aino Rönkä and Anna Anttalainen and Liisa Ukkola-Vuoti and Iiro Toppila and Johanna Vikkula and Jan Seppälä and Kristiina Vuolukka and Katja Marin and Hanne Kuitunen and Tatu Miettinen and Anu Partanen},
journal = {Annals of hematology},
year = {2026},
month = jul,
doi = {10.1007/s00277-026-07193-9},
url = {https://europepmc.org/article/MED/42894041},
note = {CC BY},
}
RIS
TY - JOUR
TI - Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study.
AU - Noora Hannuksela
AU - Outi Kuittinen
AU - Aino Rönkä
AU - Anna Anttalainen
AU - Liisa Ukkola-Vuoti
AU - Iiro Toppila
AU - Johanna Vikkula
AU - Jan Seppälä
AU - Kristiina Vuolukka
AU - Katja Marin
AU - Hanne Kuitunen
AU - Tatu Miettinen
AU - Anu Partanen
PY - 2026
DA - 2026/07/01
JO - Annals of hematology
DO - 10.1007/s00277-026-07193-9
UR - https://europepmc.org/article/MED/42894041
AB - Hodgkin lymphoma (HL) is a B-cell neoplasm with a cure rate of 90%. Previous data on late morbidity in patients with HL cover the era of older treatment modalities. This real-world study consisted of 2912 patients diagnosed with HL between 2000 and 2019 in Finland and aimed to clarify the incidence of late-onset cardiopulmonary morbidity compared to matched controls. Patient data were collected from four nationwide Finnish healthcare registries. We reported a higher occurrence of coronary artery disease in patients aged < 50 years at diagnosis than in controls (RR 3.80 (2.16-6.74), p < 0001). Additionally, a higher incidence of both heart failure (RR 1.68 (1.28-2.21), p < 0.001) and valvular heart disease (RR 1.80 (1.17-2.78), p = 0.006) was detected in patients aged ≥ 50 years at diagnosis than in the controls. Remarkably, in the < 50 years age group, the incidences of pneumonia (RR 4.89 (3.58-6.71), p < 0.001) and pulmonary embolism (RR 7.78 (2.75-21.95), p < 0.001) were higher than those in the control group. In conclusion, with the current treatment modalities, late cardiopulmonary morbidity in long-term survivors remains a great challenge. A strategy for primary prevention and early detection of late toxicity remains crucial and a critical evaluation of current treatment practices is warranted.
SN - 0939-5555
SN - 1432-0584
ER -