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Peer-reviewedCC BY 4.0Communications Biology

Biologically engineered vectors enable topical mRNA delivery for skin regeneration

  • Julie Gérard1
  • Héloïse Pilet1
  • Charbel Bouez2
  • Xun Du3
  • Yong Chen3
  • Yogeshvar N. Kalia4,5
  • Pascal Clayette1
  • Bruno A. Bernard1
  • Nicolas Grandchamp1
5 affiliations
  1. 1GEG Tech, Office : 23 rue d’Anjou, Paris, France
  2. 2International Flavors & Fragrances, 521 W 57th St, New York, NY USA
  3. 3School of Pharmacy, Nantong University, 9 Seyuan Road, Nantong, Jiangsu Province China
  4. 4School of Pharmaceutical Sciences, University of Geneva, CMU - 1 rue Michel-Servet, 1211, Geneva, Switzerland
  5. 5Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU - 1 rue Michel-Servet, 1211, Geneva, Switzerland
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Abstract

Messenger RNA therapeutics offer transient protein expression without altering the cellular genome, making them attractive for regenerative medicine, but efficient and safe delivery to the skin remains a major challenge. Lipid nanoparticles have transformed RNA delivery yet can remain limited in skin by tissue accessibility, formulation constraints and local tissue responses. Here we define Biologically Engineered Vectors (BEVs) as biologically assembled delivery particles generated through genetic or cellular engineering to transport therapeutic nucleic acids, and we develop RNA-BEVs as a platform for topical mRNA delivery. RNA-BEVs efficiently delivered functional mRNA to keratinocytes, induced transient protein expression throughout reconstructed epidermis after topical administration, and improved the histological quality of repair relative to mRNA-loaded lipid nanoparticles in a diabetic rat wound model. These findings establish RNA-BEVs as a biologically assembled platform for localized transient RNA delivery and skin regeneration.

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Cite

BibTeXRIS
BibTeX
@article{gerard2026biologically,
  title = {{Biologically engineered vectors enable topical mRNA delivery for skin regeneration}},
  author = {Julie Gérard and Héloïse Pilet and Charbel Bouez and Xun Du and Yong Chen and Yogeshvar N. Kalia and Pascal Clayette and Bruno A. Bernard and Nicolas Grandchamp},
  journal = {Communications Biology},
  year = {2026},
  month = jul,
  doi = {10.1038/s42003-026-10651-9},
  url = {https://doi.org/10.1038/s42003-026-10651-9},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Biologically engineered vectors enable topical mRNA delivery for skin regeneration
AU  - Julie Gérard
AU  - Héloïse Pilet
AU  - Charbel Bouez
AU  - Xun Du
AU  - Yong Chen
AU  - Yogeshvar N. Kalia
AU  - Pascal Clayette
AU  - Bruno A. Bernard
AU  - Nicolas Grandchamp
PY  - 2026
DA  - 2026/07/08
JO  - Communications Biology
DO  - 10.1038/s42003-026-10651-9
UR  - https://doi.org/10.1038/s42003-026-10651-9
AB  - Messenger RNA therapeutics offer transient protein expression without altering the cellular genome, making them attractive for regenerative medicine, but efficient and safe delivery to the skin remains a major challenge. Lipid nanoparticles have transformed RNA delivery yet can remain limited in skin by tissue accessibility, formulation constraints and local tissue responses. Here we define Biologically Engineered Vectors (BEVs) as biologically assembled delivery particles generated through genetic or cellular engineering to transport therapeutic nucleic acids, and we develop RNA-BEVs as a platform for topical mRNA delivery. RNA-BEVs efficiently delivered functional mRNA to keratinocytes, induced transient protein expression throughout reconstructed epidermis after topical administration, and improved the histological quality of repair relative to mRNA-loaded lipid nanoparticles in a diabetic rat wound model. These findings establish RNA-BEVs as a biologically assembled platform for localized transient RNA delivery and skin regeneration.
SN  - 2399-3642
ER  -