Combined Anterior-Posterior vs. Posterior-Only Fusion in Adult Spinal Deformity Radiographic, Clinical, and Mechanical Outcomes With Longitudinal Mixed-Effects Analysis.
5 affiliations
- 1Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA.
- 2Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
- 3Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
- 4Comprehensive Spine Center, Koc University Hospital, Istanbul, Turkey.
- 5Department of Biostatistics, Ankara University Faculty of Medicine, Ankara, Turkey.
Abstract
Study DesignRetrospective cohort study.ObjectivesTo compare radiographic, clinical, and mechanical outcomes of posterior-only versus combined anterior-posterior fusion in adult spinal deformity (ASD) patients undergoing long-segment thoracolumbar fusion with pelvic fixation.MethodsConsecutive ASD patients undergoing instrumented fusion ≥7 levels with pelvic fixation at a single center (2016-2023) were stratified by surgical approach. Longitudinal radiographic changes were analyzed using linear mixed-effects models with difference-in-differences (DiD) estimation. Mechanical complications were evaluated with Kaplan-Meier survival and Cox proportional hazards analysis.Results207 patients were included (posterior-only, n=115; combined, n=92). Mean age was 62.1 ± 11.1 years (77.8% female), with mean follow-up of 46.2 ± 21.2 months. The combined approach demonstrated significantly greater DiD estimates for lumbar lordosis (-7.8° to -9.2°, all p<0.001), relative pelvic version mismatch (+3.4° to +4.2°, all p<0.001), and GAP score (-1.8 to -2.1, all p<0.001) at all postoperative timepoints. DiD estimates were stable across three covariate specifications. Rod fractures occurred in 14.8% of posterior-only versus 3.3% of combined patients (p=0.008), with superior rod fracture-free survival in the combined cohort (log-rank p=0.019). In the primary Cox model, the combined approach showed a non-significant trend toward lower rod fracture hazard (HR 0.35, 95% CI 0.10-1.24, p=0.10). Patient-reported outcomes improved comparably in both groups.ConclusionsIn long-segment ASD fusion with pelvic fixation, the combined anterior-posterior approach was associated with greater sustained sagittal correction and lower rod fracture rates, while both approaches provided comparable clinical improvement.
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BibTeX
@article{demirci2026combined,
title = {{Combined Anterior-Posterior vs. Posterior-Only Fusion in Adult Spinal Deformity Radiographic, Clinical, and Mechanical Outcomes With Longitudinal Mixed-Effects Analysis.}},
author = {Nuri Demirci and Mohamed A Zaazoue and Caglar Yilgor and Yasemin Yavuz and Tugba Akkaya Hocagil and R Adams Cowley and Nicholas Pallotta and Munish C Gupta},
journal = {Global spine journal},
year = {2026},
month = oct,
doi = {10.1177/21925682261499343},
url = {https://europepmc.org/article/MED/42901499},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Combined Anterior-Posterior vs. Posterior-Only Fusion in Adult Spinal Deformity Radiographic, Clinical, and Mechanical Outcomes With Longitudinal Mixed-Effects Analysis.
AU - Nuri Demirci
AU - Mohamed A Zaazoue
AU - Caglar Yilgor
AU - Yasemin Yavuz
AU - Tugba Akkaya Hocagil
AU - R Adams Cowley
AU - Nicholas Pallotta
AU - Munish C Gupta
PY - 2026
DA - 2026/10/20
JO - Global spine journal
DO - 10.1177/21925682261499343
UR - https://europepmc.org/article/MED/42901499
AB - Study DesignRetrospective cohort study.ObjectivesTo compare radiographic, clinical, and mechanical outcomes of posterior-only versus combined anterior-posterior fusion in adult spinal deformity (ASD) patients undergoing long-segment thoracolumbar fusion with pelvic fixation.MethodsConsecutive ASD patients undergoing instrumented fusion ≥7 levels with pelvic fixation at a single center (2016-2023) were stratified by surgical approach. Longitudinal radiographic changes were analyzed using linear mixed-effects models with difference-in-differences (DiD) estimation. Mechanical complications were evaluated with Kaplan-Meier survival and Cox proportional hazards analysis.Results207 patients were included (posterior-only, n=115; combined, n=92). Mean age was 62.1 ± 11.1 years (77.8% female), with mean follow-up of 46.2 ± 21.2 months. The combined approach demonstrated significantly greater DiD estimates for lumbar lordosis (-7.8° to -9.2°, all p<0.001), relative pelvic version mismatch (+3.4° to +4.2°, all p<0.001), and GAP score (-1.8 to -2.1, all p<0.001) at all postoperative timepoints. DiD estimates were stable across three covariate specifications. Rod fractures occurred in 14.8% of posterior-only versus 3.3% of combined patients (p=0.008), with superior rod fracture-free survival in the combined cohort (log-rank p=0.019). In the primary Cox model, the combined approach showed a non-significant trend toward lower rod fracture hazard (HR 0.35, 95% CI 0.10-1.24, p=0.10). Patient-reported outcomes improved comparably in both groups.ConclusionsIn long-segment ASD fusion with pelvic fixation, the combined anterior-posterior approach was associated with greater sustained sagittal correction and lower rod fracture rates, while both approaches provided comparable clinical improvement.
SN - 2192-5682
SN - 2192-5690
ER -