Gastritis cystica profunda with early gastric cancer persisting for 9 years in the stage of high-grade intraepithelial neoplasia
4 affiliations
- 1Department of Gastroenterology, The First Affiliated Hospital of Shihezi University, 107 Beier Road, Shiheizi, Xinjiang 832008 China
- 2Department of Gastroenterology, Shihezi People’s Hospital, 411 Naner Xiyi Road, Shihezi, Xinjiang 832000 China
- 3Shihezi University, 221 Beisi Road, Shihezi, Xinjiang 832003 China
- 4Department of Pathology, First Affiliated Hospital, Shihezi University, 107 Beier Road, Shihezi, Xinjiang 832008 China
Abstract
Gastritis cystica profunda (GCP) is a benign lesion characterized by the submucosal proliferation of cystic gastric glands. It most frequently occurs in patients with a history of gastric surgery but is infrequently found in those with an unoperated stomach. While generally benign, GCP has been associated with gastric adenocarcinoma in some cases. We report a case of early gastric cancer (EGC) arising from GCP in a 69-year-old man with no history of gastric surgery. The lesion, which had remained in the stage of high-grade intraepithelial neoplasia for nine years, was successfully treated with endoscopic submucosal dissection (ESD). This case highlights the diagnostic challenges posed by GCP-associated lesions and suggests that such lesions may exhibit an indolent clinical course. In 2016, a gastroscopic examination revealed a 0-IIa + IIc lesion of approximately 40 mm in diameter on the greater curvature of the gastric antrum, close to the posterior wall. A biopsy confirmed high-grade intraepithelial neoplasia. The lesion was deemed indicated for ESD. However, during the procedure, a poor lifting sign following submucosal injection led to the suspicion of submucosal infiltration, and the treatment was subsequently aborted. The patient declined further treatment and opted for clinical follow-up. In 2025, a follow-up gastroscopy showed no significant change in the lesion compared to its 2016 appearance. A second ESD was successfully performed. Histopathological examination of the resected specimen confirmed the diagnosis of GCP with well-differentiated adenocarcinoma (confined to high-grade intraepithelial neoplasia). All lateral and deep margins were free of neoplasia, with no evidence of lymphatic, vascular, or perineural invasion. The surrounding gastric epithelium showed normal mucosa without dysplasia. This case highlights the diagnostic challenges posed by GCP-associated lesions and suggests that, in selected instances, such lesions may follow a relatively indolent clinical course.
Related
- Gastritis Cystica Profunda With High-Grade Dysplasia Mimicking Gastrointestinal Stromal Tumor: A Histopathological Pitfall in the Assessment of Submucosal Invasion.
- Cytokine Profiles in Cervical Intraepithelial Neoplasia: Associations with Lesion Severity and Exploratory Treatment Response
- HPV-Associated Tonsillar Intraepithelial Neoplasia and Oral High-Risk HPV mRNA as a Candidate Biomarker
- Case Report: Successful treatment of verruciform acanthotic vulvar intraepithelial neoplasia with 5-aminolevulinic acid photodynamic therapy.
- Real-world clinical outcomes of 5-aminolevulinic acid photodynamic therapy in patients with cervical intraepithelial neoplasia grade 1
BibTeX
@article{song2026gastritis,
title = {{Gastritis cystica profunda with early gastric cancer persisting for 9 years in the stage of high-grade intraepithelial neoplasia}},
author = {Jianling Song and Ruoxuan Hou and Lan Yang and Haijun Zhang and Yi Zheng},
journal = {BMC Gastroenterology},
year = {2026},
month = aug,
doi = {10.1186/s12876-026-05202-9},
url = {https://doi.org/10.1186/s12876-026-05202-9},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Gastritis cystica profunda with early gastric cancer persisting for 9 years in the stage of high-grade intraepithelial neoplasia
AU - Jianling Song
AU - Ruoxuan Hou
AU - Lan Yang
AU - Haijun Zhang
AU - Yi Zheng
PY - 2026
DA - 2026/08/10
JO - BMC Gastroenterology
DO - 10.1186/s12876-026-05202-9
UR - https://doi.org/10.1186/s12876-026-05202-9
AB - Gastritis cystica profunda (GCP) is a benign lesion characterized by the submucosal proliferation of cystic gastric glands. It most frequently occurs in patients with a history of gastric surgery but is infrequently found in those with an unoperated stomach. While generally benign, GCP has been associated with gastric adenocarcinoma in some cases. We report a case of early gastric cancer (EGC) arising from GCP in a 69-year-old man with no history of gastric surgery. The lesion, which had remained in the stage of high-grade intraepithelial neoplasia for nine years, was successfully treated with endoscopic submucosal dissection (ESD). This case highlights the diagnostic challenges posed by GCP-associated lesions and suggests that such lesions may exhibit an indolent clinical course. In 2016, a gastroscopic examination revealed a 0-IIa + IIc lesion of approximately 40 mm in diameter on the greater curvature of the gastric antrum, close to the posterior wall. A biopsy confirmed high-grade intraepithelial neoplasia. The lesion was deemed indicated for ESD. However, during the procedure, a poor lifting sign following submucosal injection led to the suspicion of submucosal infiltration, and the treatment was subsequently aborted. The patient declined further treatment and opted for clinical follow-up. In 2025, a follow-up gastroscopy showed no significant change in the lesion compared to its 2016 appearance. A second ESD was successfully performed. Histopathological examination of the resected specimen confirmed the diagnosis of GCP with well-differentiated adenocarcinoma (confined to high-grade intraepithelial neoplasia). All lateral and deep margins were free of neoplasia, with no evidence of lymphatic, vascular, or perineural invasion. The surrounding gastric epithelium showed normal mucosa without dysplasia. This case highlights the diagnostic challenges posed by GCP-associated lesions and suggests that, in selected instances, such lesions may follow a relatively indolent clinical course.
SN - 1471-230X
ER -