Atypical Cogan's Syndrome Is Common among Japanese Patients: A Case Report and Literature Review in Japan

Abstract

We report the case of a 55-year-old Japanese woman who presented with fever, headache, vertigo, sensorineural hearing loss, and scleritis, leading to a diagnosis of Cogan's syndrome (CS). Her hearing acuity recovered to previous levels after high-dose glucocorticoid treatment, despite seven weeks having passed since the onset. We reviewed 30 adult cases of Japanese CS using PubMed and Ichushi-Web. We identified several clinical features of Japanese patients with CS, including an older age of onset, less interstitial keratitis, more frequent fever and headache, elevated inflammatory marker levels, and a higher prevalence of large-vessel vasculitis, compared with studies on Caucasians.

Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: A systematic literature review
Jo Nijs, Aandrea Nees, Lorna Paul +4
PubMed15 Jul 2026Peer-reviewedLicence not stated98 citedPsychiatry & mental healthOpenAlex
Combined Triglyceride–High-density Lipoprotein Cholesterol Phenotypes and Cardiovascular Outcomes in Japanese Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Insights from Clinical Deep Data Accumulation System-PCI
Mitsukuni Kimura, Shunsuke Katsuki, Yasuhiro Nakano +26
Journal of Atherosclerosis and Thrombosis25 Aug 2026Peer-reviewedCC BY-NC-SAFull textSurgery & anaesthesiaJ-STAGE
The Diverse Clinical Spectrum of Noonan Syndrome in Pediatric Endocrinology: From Classical to Atypical Phenotypes
Sara Aszkiełowicz, Anna Łupińska, Arkadiusz Zygmunt +1
Journal of clinical medicine29 Sep 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
A rare case report: atypical presentation of Klinefelter syndrome in a 24-year-old male at suburban tertiary care hospital in Nepal
Annals of medicine and surgery (2012)3 Sep 2026Peer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
[Diagnosis and Intraoperative Decision-making in Pulmonary Sclerosing Pneumocytoma with Atypical Imaging Findings: A Case Report and Review of the Literature].
Xingyi Xu, Hui Xiao, Xiong Ye
Zhongguo fei ai za zhi = Chinese journal of lung cancer1 Aug 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeX RIS

BibTeX

@article{nagashima2026atypical,
  title = {{Atypical Cogan's Syndrome Is Common among Japanese Patients: A Case Report and Literature Review in Japan}},
  author = {Takao Nagashima and Toshikatsu Kaburaki},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.6745-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6745-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Atypical Cogan's Syndrome Is Common among Japanese Patients: A Case Report and Literature Review in Japan
AU  - Takao Nagashima
AU  - Toshikatsu Kaburaki
PY  - 2026
DA  - 2026/09/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6745-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6745-25/_article
AB  - We report the case of a 55-year-old Japanese woman who presented with fever, headache, vertigo, sensorineural hearing loss, and scleritis, leading to a diagnosis of Cogan's syndrome (CS). Her hearing acuity recovered to previous levels after high-dose glucocorticoid treatment, despite seven weeks having passed since the onset. We reviewed 30 adult cases of Japanese CS using PubMed and Ichushi-Web. We identified several clinical features of Japanese patients with CS, including an older age of onset, less interstitial keratitis, more frequent fever and headache, elevated inflammatory marker levels, and a higher prevalence of large-vessel vasculitis, compared with studies on Caucasians.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

Related

Cite