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Peer-reviewedCC BYJournal of Liposome Research

Liposomes in oral delivery: mechanisms, advances, challenges, and future perspectives

  • Patrick Pan1
  • Yuhong Ma2,1
  • Seeun Kong1
  • Kamel S. Ahmed3,1
  • Zimei Wu1
  1. 1School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland
  2. 2Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University
  3. 3Department of Pharmaceutics, Faculty of Pharmacy, Minia University
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Abstract

, Lipicur, and silymarin liposomes. This is followed by a comprehensive overview of the biological barriers for liposome absorption. The report further reviews current understanding the mechanisms for liposomes to cross the GI track and enter the bloodstream, including cellular uptake, transepithelial transport, and lymphatic transport. Formulation strategies to improve absorption such as lipid composition, surface modification techniques such as PEGylation and chitosan are discussed. Understanding these properties is essential for enhancing transepithelial transport efficiency and designing effective oral liposome delivery systems. Finally, the recent development in manufacturing scalability is also covered. Owing to their favorable properties, oral liposome delivery systems remain an active area for innovations in expanding their applications. It is anticipated that demand for oral liposomal drug‑delivery systems will continue to grow, driven by the rising prevalence of chronic diseases that require long‑term therapeutic management.

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Cite

BibTeXRIS
BibTeX
@article{pan2026liposomes,
  title = {{Liposomes in oral delivery: mechanisms, advances, challenges, and future perspectives}},
  author = {Patrick Pan and Yuhong Ma and Seeun Kong and Kamel S. Ahmed and Zimei Wu},
  journal = {Journal of Liposome Research},
  year = {2026},
  month = jun,
  doi = {10.1080/08982104.2026.2675542},
  url = {https://doi.org/10.1080/08982104.2026.2675542},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Liposomes in oral delivery: mechanisms, advances, challenges, and future perspectives
AU  - Patrick Pan
AU  - Yuhong Ma
AU  - Seeun Kong
AU  - Kamel S. Ahmed
AU  - Zimei Wu
PY  - 2026
DA  - 2026/06/03
JO  - Journal of Liposome Research
DO  - 10.1080/08982104.2026.2675542
UR  - https://doi.org/10.1080/08982104.2026.2675542
AB  - , Lipicur, and silymarin liposomes. This is followed by a comprehensive overview of the biological barriers for liposome absorption. The report further reviews current understanding the mechanisms for liposomes to cross the GI track and enter the bloodstream, including cellular uptake, transepithelial transport, and lymphatic transport. Formulation strategies to improve absorption such as lipid composition, surface modification techniques such as PEGylation and chitosan are discussed. Understanding these properties is essential for enhancing transepithelial transport efficiency and designing effective oral liposome delivery systems. Finally, the recent development in manufacturing scalability is also covered. Owing to their favorable properties, oral liposome delivery systems remain an active area for innovations in expanding their applications. It is anticipated that demand for oral liposomal drug‑delivery systems will continue to grow, driven by the rising prevalence of chronic diseases that require long‑term therapeutic management.
SN  - 0898-2104
SN  - 1532-2394
ER  -