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Peer-reviewedLicence not statedBMJ Open

Is metformin use associated with cognitive, physical and cardiovascular outcomes in older adults with type 2 diabetes? A secondary analysis of the SCOPE multicentre prospective cohort study

  • Johanna Wallensten1,2
  • Johan Ärnlöv3
  • Lucia Muglia4
  • Luca Soraci4
  • Fabrizia Lattanzio5
  • Paolo Fabbietti4
  • Rada Artzi-Medvedik6
  • Itshak Melzer6
  • Francesc Formiga7
  • Rafael Moreno-Gónzalez7
  • Tomasz Kostka8
  • Agnieszka Guligowska8
7 more authors
  • Zuzanna Chrzastek8
  • Malgorzata Piglowska8
  • Regina Roller-Wirnsberger9
  • Gerhard Wirnsberger9
  • Lisanne Tap10
  • Francesco Mattace-Raso10
  • Axel C Carlsson2,3
10 affiliations
  1. 1Department of Clinical Sciences, Danderyd Hospital, 18288 Stockholm, Sweden
  2. 2Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden
  3. 3Division of Family Medicine and Primary Health Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17177 Stockholm, Sweden
  4. 4Center for Biostatistic and Applied Geriatric Clinical Epidemiology (IRCCS INRCA), National Institute of Health and Science on Ageing, INRCA-IRCCS, Cosenza, Italy
  5. 5Italian National Research Center on Aging (IRCCS INRCA), INRCA-IRCCS, Ancona, Italy
  6. 6Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  7. 7Geriatric Unit, Internal Medicine Department, Systemic Diseases and Ageing Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Hospital Universitari de Bellvitge, Bellvitge, Spain
  8. 8Department of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Pomorska 247/249, 92-209 Lodz, Poland
  9. 9Department of Internal Medicine, Research Unit on Old Age Medicine and Lifelong Health, Medical University of Graz, Graz, Austria
  10. 10Department of Internal Medicine, Section of Geriatric Medicine, University Medical Center Rotterdam, Erasmus MC, Rotterdam, Netherlands
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Cite

BibTeXRIS
BibTeX
@article{wallensten2026metformin,
  title = {{Is metformin use associated with cognitive, physical and cardiovascular outcomes in older adults with type 2 diabetes? A secondary analysis of the SCOPE multicentre prospective cohort study}},
  author = {Johanna Wallensten and Johan Ärnlöv and Lucia Muglia and Luca Soraci and Fabrizia Lattanzio and Paolo Fabbietti and Rada Artzi-Medvedik and Itshak Melzer and Francesc Formiga and Rafael Moreno-Gónzalez and Tomasz Kostka and Agnieszka Guligowska and Zuzanna Chrzastek and Malgorzata Piglowska and Regina Roller-Wirnsberger and Gerhard Wirnsberger and Lisanne Tap and Francesco Mattace-Raso and Axel C Carlsson},
  journal = {BMJ Open},
  year = {2026},
  month = nov,
  doi = {10.1136/bmjopen-2025-114393},
  url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2025-114393},
}
RIS
TY  - JOUR
TI  - Is metformin use associated with cognitive, physical and cardiovascular outcomes in older adults with type 2 diabetes? A secondary analysis of the SCOPE multicentre prospective cohort study
AU  - Johanna Wallensten
AU  - Johan Ärnlöv
AU  - Lucia Muglia
AU  - Luca Soraci
AU  - Fabrizia Lattanzio
AU  - Paolo Fabbietti
AU  - Rada Artzi-Medvedik
AU  - Itshak Melzer
AU  - Francesc Formiga
AU  - Rafael Moreno-Gónzalez
AU  - Tomasz Kostka
AU  - Agnieszka Guligowska
AU  - Zuzanna Chrzastek
AU  - Malgorzata Piglowska
AU  - Regina Roller-Wirnsberger
AU  - Gerhard Wirnsberger
AU  - Lisanne Tap
AU  - Francesco Mattace-Raso
AU  - Axel C Carlsson
PY  - 2026
DA  - 2026/11/09
JO  - BMJ Open
DO  - 10.1136/bmjopen-2025-114393
UR  - https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2025-114393
SN  - 2044-6055
SN  - 2044-6055
ER  -