Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 31 min ago
Peer-reviewedCC BYNutrients

Longitudinal Changes in Left Ventricular Structure and Function During a Dietary Weight-Management Trial in Adults with Heart Failure, Type 2 Diabetes, and Obesity: A Secondary Analysis of Pro-HEART

  • Lorraine S. Evangelista1
  • Rebecca Meraz2
  • Alona D. Angosta2
  • Angelina P. Nguyen2
  • Kelly L. Wierenga2
  • Jennifer Kawi3
  • Michele A. Hamilton4
  • Gregg C. Fonarow5
5 affiliations
  1. 1Sue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA 92697, USA
  2. 2Louise Herrington School of Nursing, Baylor University, Dallas, TX 75246, USA
  3. 3Cizik School of Nursing, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
  4. 4Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
  5. 5Ahmanson-UCLA Cardiomyopathy Center, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Read full textPDFDOICite

Abstract

Background: Obesity is associated with adverse cardiac remodeling in heart failure (HF), but changes during dietary weight management are not well described. We examined longitudinal changes in left ventricular (LV) structure and systolic function during a dietary weight-management intervention. Methods: Pro-HEART participants were randomized to high-protein or standard-protein hypocaloric diets. LV end-diastolic dimension (LVEDD), ejection fraction (LVEF), and posterior wall thickness (LVPWT) were assessed at baseline, 3 months, and 15 months. Linear mixed-effects models tested time and diet effects. Results: At 15 months, LVEDD data were available for 31 of 92 participants (33.7%). Achieved protein intake was similar between randomized groups. Among 92 participants, LVEDD changed significantly over time (F(2, 51.20) = 7.45, p = 0.001), with model-estimated mean LVEDD decreasing from 59.00 mm at baseline to 54.56 mm at 15 months. LVEDD decreased from 3 to 15 months (−4.42 mm; 95% CI, −7.52 to −1.33; nominal p = 0.006; Holm-adjusted p = 0.012) and from baseline to 15 months (−4.44 mm; 95% CI, −6.86 to −2.02; nominal p < 0.001; Holm-adjusted p = 0.002). LVEF did not change significantly over time (overall p = 0.074); an exploratory baseline-to-15-month contrast was +4.11 percentage points (95% CI, 0.55–7.67; Holm-adjusted p = 0.072). LVPWT did not change significantly, and no diet group × time interactions were observed. Conclusions: LVEDD was lower at longer-term follow-up. LVEF did not change significantly over time, although an exploratory baseline-to-15-month contrast suggested an increase. Because both groups received hypocaloric diets, there was no non-dietary control group, and longitudinal HF medication data were unavailable, the observed cardiac changes cannot be attributed specifically to weight loss or the dietary intervention.

Related

  1. Aortic Haemodynamics Are Independent Longitudinal Determinants of Left Ventricular Function in Repaired Tetralogy of Fallot
    S. Chowdhury, P. Mitropoulou, P. Fernandes +4
    medRxivPreprintAll rights reservedFull textCardiovascular medicinemedRxiv
  2. Challenging the guidelines: longitudinal trends in left ventricular diameter and function in severe aortic regurgitation
    Shmuel Schwartzenberg, Amit Berkowitz, Tsahi T. Lerman +4
    Frontiers in Cardiovascular MedicinePeer-reviewedCC BY 4.0Full textCardiovascular medicineCrossref
  3. ST-Segment Elevation Myocardial Infarction Secondary to Aortic Root Thrombosis in a Patient With a Left Ventricular Assist Device
    Umama Gorsi, Julia Kumar, Nathan Kim +2
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Left Ventricular Global Longitudinal Strain and Ventricular Repolarization in People with HIV: A Comparative Cross-Sectional Study
    Elçin Özdemir Tutar, Yunus Emre Özbebek, Zeynep Seyma Turinay Ertop +1
    Medicina (Kaunas, Lithuania)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Outcome Stratification in Non-ST-Segment Elevation Myocardial Infarction: Standardized Assessment of Left Ventricular Global Longitudinal Strain
    Yaoyuan Xiao, Xi Li, Qinghua Fu +2
    Reviews in cardiovascular medicinePeer-reviewedCC BYFull textCardiovascular medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{evangelista2026longitudinal,
  title = {{Longitudinal Changes in Left Ventricular Structure and Function During a Dietary Weight-Management Trial in Adults with Heart Failure, Type 2 Diabetes, and Obesity: A Secondary Analysis of Pro-HEART}},
  author = {Lorraine S. Evangelista and Rebecca Meraz and Alona D. Angosta and Angelina P. Nguyen and Kelly L. Wierenga and Jennifer Kawi and Michele A. Hamilton and Gregg C. Fonarow},
  journal = {Nutrients},
  year = {2026},
  month = oct,
  doi = {10.3390/nu18193238},
  url = {https://europepmc.org/article/PMC/PMC13667116},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Longitudinal Changes in Left Ventricular Structure and Function During a Dietary Weight-Management Trial in Adults with Heart Failure, Type 2 Diabetes, and Obesity: A Secondary Analysis of Pro-HEART
AU  - Lorraine S. Evangelista
AU  - Rebecca Meraz
AU  - Alona D. Angosta
AU  - Angelina P. Nguyen
AU  - Kelly L. Wierenga
AU  - Jennifer Kawi
AU  - Michele A. Hamilton
AU  - Gregg C. Fonarow
PY  - 2026
DA  - 2026/10/01
JO  - Nutrients
DO  - 10.3390/nu18193238
UR  - https://europepmc.org/article/PMC/PMC13667116
AB  - Background: Obesity is associated with adverse cardiac remodeling in heart failure (HF), but changes during dietary weight management are not well described. We examined longitudinal changes in left ventricular (LV) structure and systolic function during a dietary weight-management intervention. Methods: Pro-HEART participants were randomized to high-protein or standard-protein hypocaloric diets. LV end-diastolic dimension (LVEDD), ejection fraction (LVEF), and posterior wall thickness (LVPWT) were assessed at baseline, 3 months, and 15 months. Linear mixed-effects models tested time and diet effects. Results: At 15 months, LVEDD data were available for 31 of 92 participants (33.7%). Achieved protein intake was similar between randomized groups. Among 92 participants, LVEDD changed significantly over time (F(2, 51.20) = 7.45, p = 0.001), with model-estimated mean LVEDD decreasing from 59.00 mm at baseline to 54.56 mm at 15 months. LVEDD decreased from 3 to 15 months (−4.42 mm; 95% CI, −7.52 to −1.33; nominal p = 0.006; Holm-adjusted p = 0.012) and from baseline to 15 months (−4.44 mm; 95% CI, −6.86 to −2.02; nominal p < 0.001; Holm-adjusted p = 0.002). LVEF did not change significantly over time (overall p = 0.074); an exploratory baseline-to-15-month contrast was +4.11 percentage points (95% CI, 0.55–7.67; Holm-adjusted p = 0.072). LVPWT did not change significantly, and no diet group × time interactions were observed. Conclusions: LVEDD was lower at longer-term follow-up. LVEF did not change significantly over time, although an exploratory baseline-to-15-month contrast suggested an increase. Because both groups received hypocaloric diets, there was no non-dietary control group, and longitudinal HF medication data were unavailable, the observed cardiac changes cannot be attributed specifically to weight loss or the dietary intervention.
SN  - 2072-6643
ER  -