Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial
- 1Vishnu dental college, Bhimavaram, Andhra pradesh, India, India
- 2University at Buffalo, State University of New York, Buffalo, NY USA
Abstract
Paediatric dental patients are particularly vulnerable to inadvertent soft-tissue injury following local anaesthesia (LA) This preliminary study evaluated. the clinical efficacy of 810-nm diode laser photobiomodulation (PBM) in reversing oral soft-tissue anaesthesia in paediatric patients. Thirty-four children aged 8–12 years requiring bilateral primary toothextractions under infiltration LA were enrolled in by consideration of ethical codes. Local anaesthesia was administered using 2% lidocaine with 1:80,000 epinephrine, as per the local infiltration anesthesia protocol. Participants were randomly allocated to receive both PBM and sham Laser with 7-10 days washout period between the two interventions. PBM was delivered using an 810-nm diode laser in continuous mode at 200 mW for 12 s per point at six predefined intraoral and extraoral sites. An independent examiner assessed soft-tissue sensation at 5-minute intervals by standardized bilateral palpation, using the non-anaesthetized side as the reference. The primary outcome was time to first assessment at which sensation on the anaesthetized side was judged normal. Data were analysed using a paired-samples t-test. Mean reflection time was significantly shorter in the PBM group (60.7 ± 27.3 min; p < 0.001) compared with the Sham lasergroup (78.2 ± 17.0 min). Subgroup analysis demonstrated significant reductions in reflection time in both maxillary and mandibular arches. Photobiomodulation using an 810-nm diode laser demonstrated a reduction in subjective soft tissue anaesthesia recovery time following infiltration LA in paediatric dental patients under the conditions tested.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10103-026-05056-3.
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BibTeX
@article{mohamed2026effect,
title = {{Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial}},
author = {Zia Ul Haque Mohamed and Penmetsa Ahalya and Chandrappa Vinay and Peddi Ravigna and Praveen Arany and KS Uloopi},
journal = {Lasers in Medical Science},
year = {2026},
month = oct,
doi = {10.1007/s10103-026-05056-3},
url = {https://doi.org/10.1007/s10103-026-05056-3},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial
AU - Zia Ul Haque Mohamed
AU - Penmetsa Ahalya
AU - Chandrappa Vinay
AU - Peddi Ravigna
AU - Praveen Arany
AU - KS Uloopi
PY - 2026
DA - 2026/10/28
JO - Lasers in Medical Science
DO - 10.1007/s10103-026-05056-3
UR - https://doi.org/10.1007/s10103-026-05056-3
AB - Paediatric dental patients are particularly vulnerable to inadvertent soft-tissue injury following local anaesthesia (LA) This preliminary study evaluated. the clinical efficacy of 810-nm diode laser photobiomodulation (PBM) in reversing oral soft-tissue anaesthesia in paediatric patients. Thirty-four children aged 8–12 years requiring bilateral primary toothextractions under infiltration LA were enrolled in by consideration of ethical codes. Local anaesthesia was administered using 2% lidocaine with 1:80,000 epinephrine, as per the local infiltration anesthesia protocol. Participants were randomly allocated to receive both PBM and sham Laser with 7-10 days washout period between the two interventions. PBM was delivered using an 810-nm diode laser in continuous mode at 200 mW for 12 s per point at six predefined intraoral and extraoral sites. An independent examiner assessed soft-tissue sensation at 5-minute intervals by standardized bilateral palpation, using the non-anaesthetized side as the reference. The primary outcome was time to first assessment at which sensation on the anaesthetized side was judged normal. Data were analysed using a paired-samples t-test. Mean reflection time was significantly shorter in the PBM group (60.7 ± 27.3 min; p < 0.001) compared with the Sham lasergroup (78.2 ± 17.0 min). Subgroup analysis demonstrated significant reductions in reflection time in both maxillary and mandibular arches. Photobiomodulation using an 810-nm diode laser demonstrated a reduction in subjective soft tissue anaesthesia recovery time following infiltration LA in paediatric dental patients under the conditions tested. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10103-026-05056-3.
SN - 0268-8921
SN - 1435-604X
ER -