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Peer-reviewedCC BY 4.0Aquaculture Nutrition

Effects of Partial Fishmeal Replacement With Methanotrophic Bacterial Protein (Methylococcus capsulatus) in Siberian Sturgeon (Acipenser baerii) on Growth Performance, Nutrient Utilization, Body Composition, Immune Responses, Liver Histology, Gene Expression, and Gut Microbiota

  • Hien Van Doan1
  • Pavel Hyrsl2
  • Eliska Zuskova3
  • Roey Angel4
  • Ales Tomcala3
  • Tram Thi Nguyen3
  • Mahyar Zare3
  • Ghasem Rashidian3
  • Vlastimil Stejskal3
  • Hung Quang Tran3
4 affiliations
  1. 1Department of Animal and Aquatic Sciences Faculty of Agriculture Chiang Mai University Chiang Mai 50200 Thailand cmu.ac.th
  2. 2Department of Experimental Biology Faculty of Science Masaryk University Kamenice 5 62500 Brno Czech Republic muni.cz
  3. 3Faculty of Fisheries and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses Institute of Aquaculture and Protection of Waters University of South Bohemia in České Budějovice Na Sádkách 1780 370 05 České Budějovice Czech Republic jcu.cz
  4. 4Institute of Soil Biology and Biogeochemistry Biology Centre CAS 37005 Ceske Budejovice Czech Republic cas.cz
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Abstract

This study evaluated the effects of dietary methanotrophic bacterial protein from Methylococcus capsulatus (MCP) as a partial replacement for fishmeal in juvenile Siberian sturgeon (Acipenser baerii). Four isonitrogenous, isolipidic, and isoenergetic diets were formulated containing 0%, 5.25%, 10.50%, or 15.75% MCP, corresponding to 0%, 25%, 50%, and 75% replacement of fishmeal, respectively. A total of 540 fish (23.15 ± 0.35 g) were randomly assigned to experimental diets in triplicate groups of 45 fish per tank over 70 days. Dietary MCP did not significantly affect growth performance, organo‐somatic indices, or serum biochemical and hematological parameters. However, MCP inclusion significantly affected the apparent digestibility of dry matter, protein, ash, phosphorus, and several amino acids, as well as immune‐related responses and hepatic lipid metabolism. Complement component 3 and lysozyme activity decreased with increasing MCP inclusion, whereas the expression of selected immune‐related genes in the head kidney and hepatic cholesterol and cholesteryl ester concentrations were altered. The intestinal microbial community remained dominated by Fusobacteriota, Firmicutes, and Proteobacteria, with no significant differences in overall community structure among dietary treatments. Overall, MCP at 5.75% supported biological responses comparable to the control diet, whereas higher inclusion levels were associated with reduced nutrient utilization and alterations in immune‐related and hepatic metabolic responses. These findings indicate that MCP can serve as a partial fishmeal substitute in Siberian sturgeon diets, although its inclusion level should be carefully considered.

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Cite

BibTeXRIS
BibTeX
@article{doan2026effects,
  title = {{Effects of Partial Fishmeal Replacement With Methanotrophic Bacterial Protein (Methylococcus capsulatus) in Siberian Sturgeon (Acipenser baerii) on Growth Performance, Nutrient Utilization, Body Composition, Immune Responses, Liver Histology, Gene Expression, and Gut Microbiota}},
  author = {Hien Van Doan and Pavel Hyrsl and Eliska Zuskova and Roey Angel and Ales Tomcala and Tram Thi Nguyen and Mahyar Zare and Ghasem Rashidian and Vlastimil Stejskal and Hung Quang Tran},
  journal = {Aquaculture Nutrition},
  year = {2026},
  month = nov,
  doi = {10.1155/anu/3788480},
  url = {https://doi.org/10.1155/anu/3788480},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Effects of Partial Fishmeal Replacement With Methanotrophic Bacterial Protein (Methylococcus capsulatus) in Siberian Sturgeon (Acipenser baerii) on Growth Performance, Nutrient Utilization, Body Composition, Immune Responses, Liver Histology, Gene Expression, and Gut Microbiota
AU  - Hien Van Doan
AU  - Pavel Hyrsl
AU  - Eliska Zuskova
AU  - Roey Angel
AU  - Ales Tomcala
AU  - Tram Thi Nguyen
AU  - Mahyar Zare
AU  - Ghasem Rashidian
AU  - Vlastimil Stejskal
AU  - Hung Quang Tran
PY  - 2026
DA  - 2026/11/02
JO  - Aquaculture Nutrition
DO  - 10.1155/anu/3788480
UR  - https://doi.org/10.1155/anu/3788480
AB  - This study evaluated the effects of dietary methanotrophic bacterial protein from Methylococcus capsulatus (MCP) as a partial replacement for fishmeal in juvenile Siberian sturgeon (Acipenser baerii). Four isonitrogenous, isolipidic, and isoenergetic diets were formulated containing 0%, 5.25%, 10.50%, or 15.75% MCP, corresponding to 0%, 25%, 50%, and 75% replacement of fishmeal, respectively. A total of 540 fish (23.15 ± 0.35 g) were randomly assigned to experimental diets in triplicate groups of 45 fish per tank over 70 days. Dietary MCP did not significantly affect growth performance, organo‐somatic indices, or serum biochemical and hematological parameters. However, MCP inclusion significantly affected the apparent digestibility of dry matter, protein, ash, phosphorus, and several amino acids, as well as immune‐related responses and hepatic lipid metabolism. Complement component 3 and lysozyme activity decreased with increasing MCP inclusion, whereas the expression of selected immune‐related genes in the head kidney and hepatic cholesterol and cholesteryl ester concentrations were altered. The intestinal microbial community remained dominated by Fusobacteriota, Firmicutes, and Proteobacteria, with no significant differences in overall community structure among dietary treatments. Overall, MCP at 5.75% supported biological responses comparable to the control diet, whereas higher inclusion levels were associated with reduced nutrient utilization and alterations in immune‐related and hepatic metabolic responses. These findings indicate that MCP can serve as a partial fishmeal substitute in Siberian sturgeon diets, although its inclusion level should be carefully considered.
SN  - 1353-5773
SN  - 1365-2095
ER  -