Trousseau Syndrome Manifesting as Recurrent Embolic Stroke in ROS1-Positive Non-Small-Cell Lung Cancer: A Case Report
- 1Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan
- 2Department of Chemical Engineering and Materials Science, Yuan-Ze University, Taoyuan City 320315, Taiwan
Abstract
Background: Trousseau syndrome is a paraneoplastic hypercoagulable state manifesting as recurrent thromboembolism. Lung adenocarcinomas harboring specific driver mutations, such as ROS1 rearrangements, are associated with a significantly increased risk of these events and related complications. Case presentation: A 61-year-old non-smoking female with stage IV ROS1-positive lung adenocarcinoma developed bilateral cerebral and cerebellar infarctions. While aspirin therapy was initiated, she still experienced a recurrent ischemic stroke involving the left middle cerebral artery, leading to a diagnosis of Trousseau syndrome. However, the course was further complicated by pneumonia and respiratory failure. Anticoagulation with apixaban was initiated. A third embolic event subsequently occurred, involving a right middle cerebral artery occlusion with associated subarachnoid hemorrhage and hemorrhagic transformation. Despite intensive management, the patient’s condition deteriorated, and she passed away. Conclusions: Trousseau syndrome significantly impairs the prognosis of lung cancer patients, especially with specific driven genes, such as ROS-1 gene re-arrangement. This case highlights the deteriorating prognosis of cancer-associated thrombosis, which can be refractory and requires heightened clinical vigilance.
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BibTeX
@article{wu2026trousseau,
title = {{Trousseau Syndrome Manifesting as Recurrent Embolic Stroke in ROS1-Positive Non-Small-Cell Lung Cancer: A Case Report}},
author = {Tsung-Ta Wu and Shih-Lung Cheng},
journal = {Journal of Clinical Medicine},
year = {2026},
month = nov,
doi = {10.3390/jcm15218743},
url = {https://www.mdpi.com/2077-0383/15/21/8743},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Trousseau Syndrome Manifesting as Recurrent Embolic Stroke in ROS1-Positive Non-Small-Cell Lung Cancer: A Case Report
AU - Tsung-Ta Wu
AU - Shih-Lung Cheng
PY - 2026
DA - 2026/11/09
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15218743
UR - https://www.mdpi.com/2077-0383/15/21/8743
AB - Background: Trousseau syndrome is a paraneoplastic hypercoagulable state manifesting as recurrent thromboembolism. Lung adenocarcinomas harboring specific driver mutations, such as ROS1 rearrangements, are associated with a significantly increased risk of these events and related complications. Case presentation: A 61-year-old non-smoking female with stage IV ROS1-positive lung adenocarcinoma developed bilateral cerebral and cerebellar infarctions. While aspirin therapy was initiated, she still experienced a recurrent ischemic stroke involving the left middle cerebral artery, leading to a diagnosis of Trousseau syndrome. However, the course was further complicated by pneumonia and respiratory failure. Anticoagulation with apixaban was initiated. A third embolic event subsequently occurred, involving a right middle cerebral artery occlusion with associated subarachnoid hemorrhage and hemorrhagic transformation. Despite intensive management, the patient’s condition deteriorated, and she passed away. Conclusions: Trousseau syndrome significantly impairs the prognosis of lung cancer patients, especially with specific driven genes, such as ROS-1 gene re-arrangement. This case highlights the deteriorating prognosis of cancer-associated thrombosis, which can be refractory and requires heightened clinical vigilance.
SN - 2077-0383
ER -